Explore CHT1/SLC5A7/CHT gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
| Target ID |
GM-T83143
|
| Target Name |
CHT1/SLC5A7/CHT
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
60482
|
| Gene ID |
100060334 (Equus caballus), 101097633 (Felis catus), 481311 (Canis lupus familiaris), 512311 (Bos taurus)
60482 (Homo sapiens), 63993 (Mus musculus), 714093 (Macaca mulatta), 85426 (Rattus norvegicus)
|
| Target Alternative Names |
SLC5A7,Slc5a7,CHT,CHT1,CMS20,HMN7A,HMND7,hCHT1,DHMNVP,Cht1,rCHT1
|
| Uniprot Accession |
Q9GZV3,Q8BGY9,Q9JMD7
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Prostate Cancer
|
| Disease from KEGG |
Cholinergic synapse, Choline metabolism in cancer
|
| Gene Ensembl |
ENSECAG00000005937, ENSCAFG00845008947, ENSBTAG00000004352, ENSG00000115665, ENSMUSG00000023945, ENSMMUG00000058650
|
| Target Classification |
|
Pre-made viral vector of CHT1/SLC5A7/CHT cDNA Clones/ORF Plasmid
CHT1/SLC5A7/CHT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo60482 | Pre-made Human SLC5A7/CHT/CHT1 siRNA oligo Duplex | 60482 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo85426 | Pre-made Rat Slc5a7/Cht1/rCHT1 siRNA oligo Duplex | 85426 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo63993 | Pre-made Mouse Slc5a7/CHT1 siRNA oligo Duplex | 63993 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714093 | Pre-made Cynomolgus/Rhesus macaque SLC5A7 siRNA oligo Duplex | 714093 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097633 | Pre-made Cat/Feline SLC5A7 siRNA oligo Duplex | 101097633 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481311 | Pre-made Dog/Canine SLC5A7 siRNA oligo Duplex | 481311 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512311 | Pre-made Bovines/Cattle SLC5A7 siRNA oligo Duplex | 512311 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060334 | Pre-made Equine/Horse SLC5A7 siRNA oligo Duplex | 100060334 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHT1/SLC5A7/CHT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T83143-Ab | Human | Anti-Human CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T83143-Ab | Rat | Anti-Rat CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T83143-Ab | Mouse | Anti-Mouse CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T83143-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T83143-Ab | Cat/Feline | Anti-Cat/Feline CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T83143-Ab | Dog/Canine | Anti-Dog/Canine CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T83143-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T83143-Ab | Equine/Horse | Anti-Equine/Horse CHT1/SLC5A7/CHT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CHT1/SLC5A7/CHT VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T83143-Ag | Human | Human CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T83143-Ag | Rat | Rat CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T83143-Ag | Mouse | Mouse CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T83143-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T83143-Ag | Cat/Feline | Cat/Feline CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T83143-Ag | Dog/Canine | Dog/Canine CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T83143-Ag | Bovines/Cattle | Bovines/Cattle CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T83143-Ag | Equine/Horse | Equine/Horse CHT1/SLC5A7/CHT VLP (virus-like particle) | HEK293 | Products Developing |
