Explore Beta Catenin/CTNNB1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
| Target ID |
GM-T82795
|
| Target Name |
Beta Catenin/CTNNB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1499
|
| Gene ID |
100055241 (Equus caballus), 101097342 (Felis catus), 12387 (Mus musculus), 1499 (Homo sapiens)
477032 (Canis lupus familiaris), 539003 (Bos taurus), 574265 (Macaca mulatta), 84353 (Rattus norvegicus)
|
| Target Alternative Names |
Beta Catenin,Beta-catenin,Bfc,CTNNB,CTNNB1,Catenin beta-1,Catnb,Ctnnb1,EVR7,Jup,MRD19,Mesc,NEDSDV,armadillo
|
| Uniprot Accession |
Q02248,P35222,B6V8E6,Q0VCX4,Q9WU82
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, breast cancer
|
| Disease from KEGG |
Rap1 signaling pathway, Wnt signaling pathway, Hippo signaling pathway, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Leukocyte transendothelial migration, Melanogenesis, Thyroid hormone signaling pathway, Cushing syndrome, Alcoholic liver disease, Alzheimer disease, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, Colorectal cancer, Endometrial cancer, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Arrhythmogenic right ventricular cardiomyopathy, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000006949, ENSMUSG00000006932, ENSG00000168036, ENSCAFG00845017609, ENSBTAG00000016420, ENSMMUG00000014627
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Beta Catenin/CTNNB1 cDNA Clones/ORF Plasmid
Beta Catenin/CTNNB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1499 | Pre-made Human CTNNB1/EVR7/CTNNB siRNA oligo Duplex | 1499 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84353 | Pre-made Rat Ctnnb1/Catnb siRNA oligo Duplex | 84353 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12387 | Pre-made Mouse Ctnnb1/Bfc/Mesc siRNA oligo Duplex | 12387 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574265 | Pre-made Cynomolgus/Rhesus macaque CTNNB1/Jup siRNA oligo Duplex | 574265 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097342 | Pre-made Cat/Feline CTNNB1 siRNA oligo Duplex | 101097342 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477032 | Pre-made Dog/Canine CTNNB1 siRNA oligo Duplex | 477032 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539003 | Pre-made Bovines/Cattle CTNNB1 siRNA oligo Duplex | 539003 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055241 | Pre-made Equine/Horse CTNNB1 siRNA oligo Duplex | 100055241 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Beta Catenin/CTNNB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82795-Ab | Human | Anti-Human Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82795-Ab | Rat | Anti-Rat Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T82795-Ab | Mouse | Anti-Mouse Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82795-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82795-Ab | Cat/Feline | Anti-Cat/Feline Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T82795-Ab | Dog/Canine | Anti-Dog/Canine Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82795-Ab | Bovines/Cattle | Anti-Bovines/Cattle Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T82795-Ab | Equine/Horse | Anti-Equine/Horse Beta Catenin/CTNNB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Beta Catenin/CTNNB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82795-Ag | Human | Human Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82795-Ag | Rat | Rat Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T82795-Ag | Mouse | Mouse Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82795-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82795-Ag | Cat/Feline | Cat/Feline Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T82795-Ag | Dog/Canine | Dog/Canine Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82795-Ag | Bovines/Cattle | Bovines/Cattle Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T82795-Ag | Equine/Horse | Equine/Horse Beta Catenin/CTNNB1 VLP (virus-like particle) | HEK293 | Products Developing |
