Explore KLKB1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T82739
|
| Target Name |
KLKB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3818
|
| Gene ID |
100056650 (Equus caballus), 101094092 (Felis catus), 16621 (Mus musculus), 25048 (Rattus norvegicus)
3818 (Homo sapiens), 533547 (Bos taurus), 696639 (Macaca mulatta)
|
| Target Alternative Names |
APS,Fletcher factor,KALP15,KLK3,KLKB1,Kal-3,Kal3,Kalp1,Kininogenin,Klk3,Klkb1,PK,PKK,PKKD,PPK,PSA,Plasma kallikrein,Plasma prekallikrein (PKK)
|
| Uniprot Accession |
P26262,P14272,P03952,Q2KJ63
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
lung cancer
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSECAG00000009884, ENSMUSG00000109764, ENSG00000164344, ENSBTAG00000009501, ENSMMUG00000011633
|
Pre-made viral vector of KLKB1 cDNA Clones/ORF Plasmid
KLKB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3818 | Pre-made Human KLKB1/PKK/PPK siRNA oligo Duplex | 3818 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25048 | Pre-made Rat Klkb1/PK/Klk3 siRNA oligo Duplex | 25048 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16621 | Pre-made Mouse Klkb1/APS/PSA siRNA oligo Duplex | 16621 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696639 | Pre-made Cynomolgus/Rhesus macaque KLKB1 siRNA oligo Duplex | 696639 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094092 | Pre-made Cat/Feline KLKB1 siRNA oligo Duplex | 101094092 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533547 | Pre-made Bovines/Cattle KLKB1 siRNA oligo Duplex | 533547 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056650 | Pre-made Equine/Horse KLKB1 siRNA oligo Duplex | 100056650 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KLKB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82739-Ab | Human | Anti-Human KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82739-Ab | Rat | Anti-Rat KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T82739-Ab | Mouse | Anti-Mouse KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82739-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82739-Ab | Cat/Feline | Anti-Cat/Feline KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82739-Ab | Bovines/Cattle | Anti-Bovines/Cattle KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T82739-Ab | Equine/Horse | Anti-Equine/Horse KLKB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KLKB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82739-Ag | Human | Human KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82739-Ag | Rat | Rat KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T82739-Ag | Mouse | Mouse KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82739-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82739-Ag | Cat/Feline | Cat/Feline KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82739-Ag | Bovines/Cattle | Bovines/Cattle KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T82739-Ag | Equine/Horse | Equine/Horse KLKB1 VLP (virus-like particle) | HEK293 | Products Developing |
