Explore AXL gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]
| Target ID |
GM-T82383
|
| Target Name |
AXL
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
558
|
| Gene ID |
100064907 (Equus caballus), 101086688 (Felis catus), 26362 (Mus musculus), 308444 (Rattus norvegicus)
484490 (Canis lupus familiaris), 516598 (Bos taurus), 558 (Homo sapiens), 706123 (Macaca mulatta)
|
| Target Alternative Names |
ARK,AXL,AXL oncogene,AXL3,Ark,Axl,JTK11,Tyro7,Tyrosine-protein kinase receptor UFO,UFO,Ufo
|
| Uniprot Accession |
Q00993,P30530
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance
|
| Gene Ensembl |
ENSECAG00000011471, ENSMUSG00000002602, ENSCAFG00845002569, ENSBTAG00000003166, ENSG00000167601, ENSMMUG00000009145
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of AXL cDNA Clones/ORF Plasmid
AXL siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo558 | Pre-made Human AXL/ARK/UFO siRNA oligo Duplex | 558 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo308444 | Pre-made Rat Axl siRNA oligo Duplex | 308444 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26362 | Pre-made Mouse Axl/Ark/Ufo siRNA oligo Duplex | 26362 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706123 | Pre-made Cynomolgus/Rhesus macaque AXL siRNA oligo Duplex | 706123 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086688 | Pre-made Cat/Feline AXL siRNA oligo Duplex | 101086688 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484490 | Pre-made Dog/Canine AXL siRNA oligo Duplex | 484490 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo516598 | Pre-made Bovines/Cattle AXL siRNA oligo Duplex | 516598 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064907 | Pre-made Equine/Horse AXL siRNA oligo Duplex | 100064907 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
AXL antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82383-Ab | Human | Anti-Human AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82383-Ab | Rat | Anti-Rat AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T82383-Ab | Mouse | Anti-Mouse AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82383-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82383-Ab | Cat/Feline | Anti-Cat/Feline AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T82383-Ab | Dog/Canine | Anti-Dog/Canine AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82383-Ab | Bovines/Cattle | Anti-Bovines/Cattle AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T82383-Ab | Equine/Horse | Anti-Equine/Horse AXL monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
AXL VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82383-Ag | Human | Human AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82383-Ag | Rat | Rat AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T82383-Ag | Mouse | Mouse AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82383-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82383-Ag | Cat/Feline | Cat/Feline AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T82383-Ag | Dog/Canine | Dog/Canine AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82383-Ag | Bovines/Cattle | Bovines/Cattle AXL VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T82383-Ag | Equine/Horse | Equine/Horse AXL VLP (virus-like particle) | HEK293 | Products Developing |
