Explore CEACAM1/CD66a gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
| Target ID |
GM-T82105
|
| Target Name |
CEACAM1/CD66a
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
634
|
| Gene ID |
101086271 (Felis catus), 404118 (Bos taurus), 634 (Homo sapiens), 708200 (Macaca mulatta) 81613 (Rattus norvegicus)
|
| Target Alternative Names |
BGP,BGP1,BGPI,BGPR,Bgp,Biliary glycoprotein 1 (BGP-1),CD66a,CEACAM1,CEACAM8,Carcinoembryonic antigen-related cell adhesion molecule 1 (CEA cell adhesion molecule 1),Ccam1,Ceacam1,Cell adhesion molecule CEACAM1
|
| Uniprot Accession |
P13688,P16573
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, Prostate Cancer, Non-small cell lung carcinoma
|
| Gene Ensembl |
ENSBTAG00000005615, ENSG00000079385, ENSMMUG00000038920
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CEACAM1/CD66a cDNA Clones/ORF Plasmid
CEACAM1/CD66a siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo634 | Pre-made Human CEACAM1/BGP/BGP1 siRNA oligo Duplex | 634 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81613 | Pre-made Rat Ceacam1/Bgp/BGPR siRNA oligo Duplex | 81613 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708200 | Pre-made Cynomolgus/Rhesus macaque CEACAM1 siRNA oligo Duplex | 708200 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086271 | Pre-made Cat/Feline CEACAM1 siRNA oligo Duplex | 101086271 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404118 | Pre-made Bovines/Cattle CEACAM1/CEACAM8 siRNA oligo Duplex | 404118 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
CEACAM1/CD66a antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82105-Ab | Human | Anti-Human CEACAM1/CD66a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82105-Ab | Rat | Anti-Rat CEACAM1/CD66a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82105-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CEACAM1/CD66a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82105-Ab | Cat/Feline | Anti-Cat/Feline CEACAM1/CD66a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82105-Ab | Bovines/Cattle | Anti-Bovines/Cattle CEACAM1/CD66a monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CEACAM1/CD66a VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82105-Ag | Human | Human CEACAM1/CD66a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82105-Ag | Rat | Rat CEACAM1/CD66a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82105-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CEACAM1/CD66a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82105-Ag | Cat/Feline | Cat/Feline CEACAM1/CD66a VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82105-Ag | Bovines/Cattle | Bovines/Cattle CEACAM1/CD66a VLP (virus-like particle) | HEK293 | Products Developing |