Explore TLR2/CD282 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
| Target ID |
GM-T82078
|
| Target Name |
TLR2/CD282
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7097
|
| Gene ID |
100009701 (Equus caballus), 24088 (Mus musculus), 281534 (Bos taurus), 310553 (Rattus norvegicus) 448807 (Canis lupus familiaris), 493797 (Felis catus), 574290 (Macaca mulatta), 7097 (Homo sapiens)
|
| Target Alternative Names |
CD282,Ly105,TIL4,TLR2,Tlr2,Toll-like receptor 2,Toll/interleukin-1 receptor-like protein 4
|
| Uniprot Accession |
Q6T752,Q9QUN7,Q95LA9,Q689D1,B3Y618,O60603
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Breast Cancer
|
| Disease from KEGG |
Phagosome, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Legionellosis, Leishmaniasis, Chagas disease, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Epstein-Barr virus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease, Rheumatoid arthritis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000018028, ENSMUSG00000027995, ENSBTAG00000008008, ENSMMUG00000015847, ENSG00000137462
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of TLR2/CD282 cDNA Clones/ORF Plasmid
TLR2/CD282 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7097 | Pre-made Human TLR2/TIL4/CD282 siRNA oligo Duplex | 7097 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo310553 | Pre-made Rat Tlr2 siRNA oligo Duplex | 310553 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24088 | Pre-made Mouse Tlr2/Ly105 siRNA oligo Duplex | 24088 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574290 | Pre-made Cynomolgus/Rhesus macaque TLR2 siRNA oligo Duplex | 574290 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493797 | Pre-made Cat/Feline TLR2 siRNA oligo Duplex | 493797 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo448807 | Pre-made Dog/Canine TLR2 siRNA oligo Duplex | 448807 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281534 | Pre-made Bovines/Cattle TLR2 siRNA oligo Duplex | 281534 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100009701 | Pre-made Equine/Horse TLR2 siRNA oligo Duplex | 100009701 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TLR2/CD282 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82078-Ab | Human | Anti-Human TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82078-Ab | Rat | Anti-Rat TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T82078-Ab | Mouse | Anti-Mouse TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82078-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82078-Ab | Cat/Feline | Anti-Cat/Feline TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T82078-Ab | Dog/Canine | Anti-Dog/Canine TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82078-Ab | Bovines/Cattle | Anti-Bovines/Cattle TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T82078-Ab | Equine/Horse | Anti-Equine/Horse TLR2/CD282 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TLR2/CD282 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82078-Ag | Human | Human TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82078-Ag | Rat | Rat TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T82078-Ag | Mouse | Mouse TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82078-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82078-Ag | Cat/Feline | Cat/Feline TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T82078-Ag | Dog/Canine | Dog/Canine TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82078-Ag | Bovines/Cattle | Bovines/Cattle TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T82078-Ag | Equine/Horse | Equine/Horse TLR2/CD282 VLP (virus-like particle) | HEK293 | Products Developing |