Explore BACE1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
| Target ID |
GM-T79031
|
| Target Name |
BACE1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
23621
|
| Gene ID |
100071137 (Equus caballus), 101086840 (Felis catus), 23621 (Homo sapiens), 23821 (Mus musculus)
29392 (Rattus norvegicus), 489390 (Canis lupus familiaris), 614333 (Bos taurus), 697694 (Macaca mulatta)
|
| Target Alternative Names |
ASP2,Asp 2),Aspartyl protease 2 (ASP2,BACE,BACE1,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1),HSPC104,Memapsin-2,Membrane-associated aspartic protease 2
|
| Uniprot Accession |
P56817,P56818,P56819,Q2HJ40
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000012427, ENSG00000186318, ENSMUSG00000032086, ENSCAFG00845003800, ENSBTAG00000019365, ENSMMUG00000007785
|
Pre-made viral vector of BACE1 cDNA Clones/ORF Plasmid
BACE1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo23621 | Pre-made Human BACE1/ASP2/BACE siRNA oligo Duplex | 23621 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29392 | Pre-made Rat Bace1/Bace siRNA oligo Duplex | 29392 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo23821 | Pre-made Mouse Bace1/ASP2/Bace siRNA oligo Duplex | 23821 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697694 | Pre-made Cynomolgus/Rhesus macaque BACE1 siRNA oligo Duplex | 697694 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086840 | Pre-made Cat/Feline BACE1 siRNA oligo Duplex | 101086840 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489390 | Pre-made Dog/Canine BACE1/ASP2 siRNA oligo Duplex | 489390 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo614333 | Pre-made Bovines/Cattle BACE1 siRNA oligo Duplex | 614333 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071137 | Pre-made Equine/Horse BACE1 siRNA oligo Duplex | 100071137 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BACE1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T79031-Ab | Human | Anti-Human BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T79031-Ab | Rat | Anti-Rat BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T79031-Ab | Mouse | Anti-Mouse BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T79031-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T79031-Ab | Cat/Feline | Anti-Cat/Feline BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T79031-Ab | Dog/Canine | Anti-Dog/Canine BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T79031-Ab | Bovines/Cattle | Anti-Bovines/Cattle BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T79031-Ab | Equine/Horse | Anti-Equine/Horse BACE1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
BACE1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T79031-Ag | Human | Human BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T79031-Ag | Rat | Rat BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T79031-Ag | Mouse | Mouse BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T79031-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T79031-Ag | Cat/Feline | Cat/Feline BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T79031-Ag | Dog/Canine | Dog/Canine BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T79031-Ag | Bovines/Cattle | Bovines/Cattle BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T79031-Ag | Equine/Horse | Equine/Horse BACE1 VLP (virus-like particle) | HEK293 | Products Developing |
