Explore TYK2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
| Target ID |
GM-T78932
|
| Target Name |
TYK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7297
|
| Gene ID |
100146182 (Equus caballus), 100361294 (Rattus norvegicus), 101090171 (Felis catus), 476714 (Canis lupus familiaris)
512484 (Bos taurus), 54721 (Mus musculus), 574130 (Macaca mulatta), 7297 (Homo sapiens)
|
| Target Alternative Names |
IMD35,JTK1,Non-receptor tyrosine-protein kinase TYK2,TYK2,Tyk2
|
| Uniprot Accession |
Q9R117,P29597
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Osteoclast differentiation, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000020260, ENSCAFG00845027438, ENSBTAG00000011698, ENSMUSG00000032175, ENSMMUG00000003110, ENSG00000105397
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
TYK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7297 | Pre-made Human TYK2/JTK1/IMD35 siRNA oligo Duplex | 7297 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100361294 | Pre-made Rat Tyk2 siRNA oligo Duplex | 100361294 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54721 | Pre-made Mouse Tyk2/JTK1 siRNA oligo Duplex | 54721 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574130 | Pre-made Cynomolgus/Rhesus macaque TYK2 siRNA oligo Duplex | 574130 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090171 | Pre-made Cat/Feline TYK2 siRNA oligo Duplex | 101090171 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476714 | Pre-made Dog/Canine TYK2 siRNA oligo Duplex | 476714 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512484 | Pre-made Bovines/Cattle TYK2 siRNA oligo Duplex | 512484 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146182 | Pre-made Equine/Horse TYK2 siRNA oligo Duplex | 100146182 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TYK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T78932-Ab | Human | Anti-Human TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T78932-Ab | Rat | Anti-Rat TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T78932-Ab | Mouse | Anti-Mouse TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T78932-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T78932-Ab | Cat/Feline | Anti-Cat/Feline TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T78932-Ab | Dog/Canine | Anti-Dog/Canine TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T78932-Ab | Bovines/Cattle | Anti-Bovines/Cattle TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T78932-Ab | Equine/Horse | Anti-Equine/Horse TYK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TYK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T78932-Ag | Human | Human TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T78932-Ag | Rat | Rat TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T78932-Ag | Mouse | Mouse TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T78932-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T78932-Ag | Cat/Feline | Cat/Feline TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T78932-Ag | Dog/Canine | Dog/Canine TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T78932-Ag | Bovines/Cattle | Bovines/Cattle TYK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T78932-Ag | Equine/Horse | Equine/Horse TYK2 recombinant protein | Mammalian cell | Detail |
