Explore TFPI gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
| Target ID |
GM-T78890
|
| Target Name |
TFPI
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7035
|
| Gene ID |
100068873 (Equus caballus), 101098813 (Felis catus), 21788 (Mus musculus), 29436 (Rattus norvegicus)
403921 (Canis lupus familiaris), 508763 (Bos taurus), 613026 (Macaca mulatta), 7035 (Homo sapiens)
|
| Target Alternative Names |
A630013F22Rik,EPI,Extrinsic pathway inhibitor (EPI),LACI,Lipoprotein-associated coagulation inhibitor (LACI),TFI,TFPI,TFPI1,Tfpi,Tissue factor pathway inhibitor
|
| Uniprot Accession |
O54819,Q02445,Q28864,P10646
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer, Lung Cancer
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSECAG00000021849, ENSMUSG00000027082, ENSCAFG00845018905, ENSBTAG00000049919, ENSMMUG00000009448, ENSG00000003436
|
Pre-made viral vector of TFPI cDNA Clones/ORF Plasmid
TFPI siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7035 | Pre-made Human TFPI/EPI/TFI siRNA oligo Duplex | 7035 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29436 | Pre-made Rat Tfpi siRNA oligo Duplex | 29436 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21788 | Pre-made Mouse Tfpi/EPI/LACI siRNA oligo Duplex | 21788 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613026 | Pre-made Cynomolgus/Rhesus macaque TFPI/EPI/LACI siRNA oligo Duplex | 613026 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098813 | Pre-made Cat/Feline TFPI siRNA oligo Duplex | 101098813 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403921 | Pre-made Dog/Canine TFPI siRNA oligo Duplex | 403921 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508763 | Pre-made Bovines/Cattle TFPI siRNA oligo Duplex | 508763 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068873 | Pre-made Equine/Horse TFPI siRNA oligo Duplex | 100068873 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TFPI antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T78890-Ab | Human | Anti-Human TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T78890-Ab | Rat | Anti-Rat TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T78890-Ab | Mouse | Anti-Mouse TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T78890-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T78890-Ab | Cat/Feline | Anti-Cat/Feline TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T78890-Ab | Dog/Canine | Anti-Dog/Canine TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T78890-Ab | Bovines/Cattle | Anti-Bovines/Cattle TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T78890-Ab | Equine/Horse | Anti-Equine/Horse TFPI monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TFPI VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T78890-Ag | Human | Human TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T78890-Ag | Rat | Rat TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T78890-Ag | Mouse | Mouse TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T78890-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T78890-Ag | Cat/Feline | Cat/Feline TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T78890-Ag | Dog/Canine | Dog/Canine TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T78890-Ag | Bovines/Cattle | Bovines/Cattle TFPI VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T78890-Ag | Equine/Horse | Equine/Horse TFPI VLP (virus-like particle) | HEK293 | Products Developing |
