Explore DR4/TNFRSF10A/CD261/TRAIL-R1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T77645
|
| Target Name |
DR4/TNFRSF10A/CD261/TRAIL-R1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8797
|
| Gene ID |
716826 (Macaca mulatta), 8797 (Homo sapiens)
|
| Target Alternative Names |
TNFRSF10A,DR4,APO2,CD261,TRAILR1,TRAILR-1
|
| Uniprot Accession |
O00220
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, p53 signaling pathway, Apoptosis, Natural killer cell mediated cytotoxicity, Pathogenic Escherichia coli infection, Influenza A, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSMMUG00000007542, ENSG00000104689
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of DR4/TNFRSF10A/CD261/TRAIL-R1 cDNA Clones/ORF Plasmid
DR4/TNFRSF10A/CD261/TRAIL-R1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8797 | Pre-made Human TNFRSF10A/DR4/APO2 siRNA oligo Duplex | 8797 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716826 | Pre-made Cynomolgus/Rhesus macaque TNFRSF10A siRNA oligo Duplex | 716826 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
DR4/TNFRSF10A/CD261/TRAIL-R1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T77645-Ab | Human | Anti-Human DR4/TNFRSF10A/CD261/TRAIL-R1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T77645-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DR4/TNFRSF10A/CD261/TRAIL-R1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
DR4/TNFRSF10A/CD261/TRAIL-R1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T77645-Ag | Human | Human DR4/TNFRSF10A/CD261/TRAIL-R1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T77645-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DR4/TNFRSF10A/CD261/TRAIL-R1 VLP (virus-like particle) | HEK293 | Products Developing |
