Explore ITPR2/IP3R2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
| Target ID |
GM-T76678
|
| Target Name |
ITPR2/IP3R2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3709
|
| Gene ID |
100064557 (Equus caballus), 101101230 (Felis catus), 16439 (Mus musculus), 281878 (Bos taurus)
3709 (Homo sapiens), 486628 (Canis lupus familiaris), 708714 (Macaca mulatta), 81678 (Rattus norvegicus)
|
| Target Alternative Names |
ITPR2,Itpr2,Ip3r2,Itpr5,insP3R2,InsP3R-2,InsP3R-5,ANHD,IP3R2,CFAP48,INSP3R2
|
| Uniprot Accession |
Q9Z329,Q8WN96,Q14571,P29995
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Calcium signaling pathway, cGMP-PKG signaling pathway, Apoptosis, Cellular senescence, Vascular smooth muscle contraction, Gap junction, Platelet activation, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Thyroid hormone synthesis, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000008131, ENSMUSG00000030287, ENSBTAG00000002313, ENSG00000123104, ENSCAFG00845025705, ENSMMUG00000023128
|
| Target Classification |
|
ITPR2/IP3R2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3709 | Pre-made Human ITPR2/ANHD/IP3R2 siRNA oligo Duplex | 3709 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81678 | Pre-made Rat Itpr2 siRNA oligo Duplex | 81678 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16439 | Pre-made Mouse Itpr2/Ip3r2/Itpr5 siRNA oligo Duplex | 16439 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708714 | Pre-made Cynomolgus/Rhesus macaque ITPR2 siRNA oligo Duplex | 708714 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101230 | Pre-made Cat/Feline ITPR2 siRNA oligo Duplex | 101101230 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486628 | Pre-made Dog/Canine ITPR2 siRNA oligo Duplex | 486628 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281878 | Pre-made Bovines/Cattle ITPR2/insP3R2 siRNA oligo Duplex | 281878 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064557 | Pre-made Equine/Horse ITPR2 siRNA oligo Duplex | 100064557 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ITPR2/IP3R2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T76678-Ab | Human | Anti-Human ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T76678-Ab | Rat | Anti-Rat ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T76678-Ab | Mouse | Anti-Mouse ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T76678-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T76678-Ab | Cat/Feline | Anti-Cat/Feline ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T76678-Ab | Dog/Canine | Anti-Dog/Canine ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T76678-Ab | Bovines/Cattle | Anti-Bovines/Cattle ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T76678-Ab | Equine/Horse | Anti-Equine/Horse ITPR2/IP3R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ITPR2/IP3R2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T76678-Ag | Human | Human ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T76678-Ag | Rat | Rat ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T76678-Ag | Mouse | Mouse ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T76678-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T76678-Ag | Cat/Feline | Cat/Feline ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T76678-Ag | Dog/Canine | Dog/Canine ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T76678-Ag | Bovines/Cattle | Bovines/Cattle ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T76678-Ag | Equine/Horse | Equine/Horse ITPR2/IP3R2 VLP (virus-like particle) | HEK293 | Products Developing |
