Explore METAP2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
| Target ID |
GM-T75596
|
| Target Name |
METAP2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10988
|
| Gene ID |
100052132 (Equus caballus), 101082672 (Felis catus), 10988 (Homo sapiens), 404150 (Bos taurus)
475429 (Canis lupus familiaris), 56307 (Mus musculus), 64370 (Rattus norvegicus), 712400 (Macaca mulatta)
|
| Target Alternative Names |
4930584B20Rik,A930035J23Rik,Amp2,Initiation factor 2-associated 67 kDa glycoprotein (p67,MAP 2,MAP2,METAP2,MNPEP,MetAP 2,Metap2,Methionine aminopeptidase 2,Mnpep,Peptidase M,p67,p67eIF2,p67eIF2)
|
| Uniprot Accession |
P50579,Q3ZC89,O08663,P38062
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Lung Cancer
|
| Gene Ensembl |
ENSECAG00000015390, ENSG00000111142, ENSBTAG00000019944, ENSCAFG00845023414, ENSMUSG00000036112, ENSMMUG00000062006
|
Pre-made viral vector of METAP2 cDNA Clones/ORF Plasmid
METAP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10988 | Pre-made Human METAP2/MAP2/MNPEP siRNA oligo Duplex | 10988 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64370 | Pre-made Rat Metap2/p67/Amp2 siRNA oligo Duplex | 64370 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56307 | Pre-made Mouse Metap2/p67/Amp2 siRNA oligo Duplex | 56307 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712400 | Pre-made Cynomolgus/Rhesus macaque METAP2 siRNA oligo Duplex | 712400 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082672 | Pre-made Cat/Feline METAP2 siRNA oligo Duplex | 101082672 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475429 | Pre-made Dog/Canine METAP2 siRNA oligo Duplex | 475429 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404150 | Pre-made Bovines/Cattle METAP2/p67/p67eIF2 siRNA oligo Duplex | 404150 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052132 | Pre-made Equine/Horse METAP2 siRNA oligo Duplex | 100052132 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
METAP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T75596-Ab | Human | Anti-Human METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T75596-Ab | Rat | Anti-Rat METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T75596-Ab | Mouse | Anti-Mouse METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T75596-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T75596-Ab | Cat/Feline | Anti-Cat/Feline METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T75596-Ab | Dog/Canine | Anti-Dog/Canine METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T75596-Ab | Bovines/Cattle | Anti-Bovines/Cattle METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T75596-Ab | Equine/Horse | Anti-Equine/Horse METAP2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
METAP2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T75596-Ag | Human | Human METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T75596-Ag | Rat | Rat METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T75596-Ag | Mouse | Mouse METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T75596-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T75596-Ag | Cat/Feline | Cat/Feline METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T75596-Ag | Dog/Canine | Dog/Canine METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T75596-Ag | Bovines/Cattle | Bovines/Cattle METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T75596-Ag | Equine/Horse | Equine/Horse METAP2 VLP (virus-like particle) | HEK293 | Products Developing |
