Explore MYD88 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
| Target ID |
GM-T75476
|
| Target Name |
MYD88
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4615
|
| Gene ID |
100053940 (Equus caballus), 101087092 (Felis catus), 17874 (Mus musculus), 301059 (Rattus norvegicus) 444881 (Bos taurus), 4615 (Homo sapiens), 477024 (Canis lupus familiaris), 696494 (Macaca mulatta)
|
| Target Alternative Names |
IMD68,MYD88,MYD88D,Myd88,Myeloid differentiation primary response protein MyD88,WM1
|
| Uniprot Accession |
P22366,Q6Y1S1,Q599T9,Q99836,B3Y683
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, NF-kappa B signaling pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Alcoholic liver disease, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Influenza A, Epstein-Barr virus infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000001774, ENSMUSG00000032508, ENSBTAG00000000563, ENSG00000172936, ENSCAFG00845029799, ENSMMUG00000000995
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MYD88 cDNA Clones/ORF Plasmid
MYD88 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4615 | Pre-made Human MYD88/WM1/IMD68 siRNA oligo Duplex | 4615 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo301059 | Pre-made Rat Myd88 siRNA oligo Duplex | 301059 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17874 | Pre-made Mouse Myd88 siRNA oligo Duplex | 17874 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696494 | Pre-made Cynomolgus/Rhesus macaque MYD88 siRNA oligo Duplex | 696494 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087092 | Pre-made Cat/Feline MYD88 siRNA oligo Duplex | 101087092 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477024 | Pre-made Dog/Canine MYD88 siRNA oligo Duplex | 477024 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo444881 | Pre-made Bovines/Cattle MYD88 siRNA oligo Duplex | 444881 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053940 | Pre-made Equine/Horse MYD88 siRNA oligo Duplex | 100053940 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MYD88 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T75476-Ab | Human | Anti-Human MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T75476-Ab | Rat | Anti-Rat MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T75476-Ab | Mouse | Anti-Mouse MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T75476-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T75476-Ab | Cat/Feline | Anti-Cat/Feline MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T75476-Ab | Dog/Canine | Anti-Dog/Canine MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T75476-Ab | Bovines/Cattle | Anti-Bovines/Cattle MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T75476-Ab | Equine/Horse | Anti-Equine/Horse MYD88 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MYD88 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T75476-Ag | Human | Human MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T75476-Ag | Rat | Rat MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T75476-Ag | Mouse | Mouse MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T75476-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T75476-Ag | Cat/Feline | Cat/Feline MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T75476-Ag | Dog/Canine | Dog/Canine MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T75476-Ag | Bovines/Cattle | Bovines/Cattle MYD88 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T75476-Ag | Equine/Horse | Equine/Horse MYD88 recombinant protein | Mammalian cell | Detail |