Explore KCNQ2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T74483
|
| Target Name |
KCNQ2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3785
|
| Gene ID |
100146986 (Equus caballus), 101101044 (Felis catus), 16536 (Mus musculus), 170848 (Rattus norvegicus)
3785 (Homo sapiens), 505963 (Bos taurus), 612515 (Canis lupus familiaris), 719614 (Macaca mulatta)
|
| Target Alternative Names |
BFNC,DEE7,EBN,EBN1,ENB1,HNSPC,KCNA11,KCNQ2,KQT-like 2,KQT2,KV7.2,Kcnq2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Nmf134,Potassium voltage-gated channel subfamily KQT member 2,Voltage-gated potassium channel subunit Kv7.2
|
| Uniprot Accession |
Q9Z351,O88943,O43526
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Cholinergic synapse
|
| Gene Ensembl |
ENSECAG00000020526, ENSMUSG00000016346, ENSG00000075043, ENSBTAG00000003030, ENSCAFG00845021011, ENSMMUG00000015918
|
| Target Classification |
Ion Channel
|
Pre-made viral vector of KCNQ2 cDNA Clones/ORF Plasmid
KCNQ2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3785 | Pre-made Human KCNQ2/EBN/BFNC siRNA oligo Duplex | 3785 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170848 | Pre-made Rat Kcnq2 siRNA oligo Duplex | 170848 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16536 | Pre-made Mouse Kcnq2/KQT2/HNSPC siRNA oligo Duplex | 16536 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719614 | Pre-made Cynomolgus/Rhesus macaque KCNQ2 siRNA oligo Duplex | 719614 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101044 | Pre-made Cat/Feline KCNQ2 siRNA oligo Duplex | 101101044 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo612515 | Pre-made Dog/Canine KCNQ2 siRNA oligo Duplex | 612515 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505963 | Pre-made Bovines/Cattle KCNQ2 siRNA oligo Duplex | 505963 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146986 | Pre-made Equine/Horse KCNQ2 siRNA oligo Duplex | 100146986 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNQ2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T74483-Ab | Human | Anti-Human KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T74483-Ab | Rat | Anti-Rat KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T74483-Ab | Mouse | Anti-Mouse KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T74483-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T74483-Ab | Cat/Feline | Anti-Cat/Feline KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T74483-Ab | Dog/Canine | Anti-Dog/Canine KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T74483-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T74483-Ab | Equine/Horse | Anti-Equine/Horse KCNQ2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNQ2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T74483-Ag | Human | Human KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T74483-Ag | Rat | Rat KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T74483-Ag | Mouse | Mouse KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T74483-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T74483-Ag | Cat/Feline | Cat/Feline KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T74483-Ag | Dog/Canine | Dog/Canine KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T74483-Ag | Bovines/Cattle | Bovines/Cattle KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T74483-Ag | Equine/Horse | Equine/Horse KCNQ2 VLP (virus-like particle) | HEK293 | Products Developing |
