Explore CHRNB4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T73724
|
| Target Name |
CHRNB4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1143
|
| Gene ID |
100060486 (Equus caballus), 101089940 (Felis catus), 106996685 (Macaca mulatta), 108015 (Mus musculus)
1143 (Homo sapiens), 25103 (Rattus norvegicus), 282181 (Bos taurus), 482110 (Canis lupus familiaris)
|
| Target Alternative Names |
Acrb-4,Acrb4,CHRNB4,Chrnb4,Neuronal acetylcholine receptor subunit beta-4,nicb4
|
| Uniprot Accession |
Q8R493,P30926,P12392,Q8SPU6
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Cholinergic synapse, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000000659, ENSMMUG00000007541, ENSMUSG00000035200, ENSG00000117971, ENSBTAG00000003132, ENSCAFG00845012797
|
Pre-made viral vector of CHRNB4 cDNA Clones/ORF Plasmid
CHRNB4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1143 | Pre-made Human CHRNB4 siRNA oligo Duplex | 1143 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25103 | Pre-made Rat Chrnb4 siRNA oligo Duplex | 25103 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo108015 | Pre-made Mouse Chrnb4/Acrb4/Acrb-4 siRNA oligo Duplex | 108015 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106996685 | Pre-made Cynomolgus/Rhesus macaque CHRNB4/nicb4 siRNA oligo Duplex | 106996685 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089940 | Pre-made Cat/Feline CHRNB4 siRNA oligo Duplex | 101089940 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482110 | Pre-made Dog/Canine CHRNB4 siRNA oligo Duplex | 482110 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282181 | Pre-made Bovines/Cattle CHRNB4 siRNA oligo Duplex | 282181 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060486 | Pre-made Equine/Horse CHRNB4 siRNA oligo Duplex | 100060486 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHRNB4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T73724-Ab | Human | Anti-Human CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T73724-Ab | Rat | Anti-Rat CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T73724-Ab | Mouse | Anti-Mouse CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T73724-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T73724-Ab | Cat/Feline | Anti-Cat/Feline CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T73724-Ab | Dog/Canine | Anti-Dog/Canine CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T73724-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T73724-Ab | Equine/Horse | Anti-Equine/Horse CHRNB4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CHRNB4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T73724-Ag | Human | Human CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T73724-Ag | Rat | Rat CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T73724-Ag | Mouse | Mouse CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T73724-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T73724-Ag | Cat/Feline | Cat/Feline CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T73724-Ag | Dog/Canine | Dog/Canine CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T73724-Ag | Bovines/Cattle | Bovines/Cattle CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T73724-Ag | Equine/Horse | Equine/Horse CHRNB4 VLP (virus-like particle) | HEK293 | Products Developing |
