Explore NR3C2/MR gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
| Target ID |
GM-T72168
|
| Target Name |
NR3C2/MR
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4306
|
| Gene ID |
100062570 (Equus caballus), 101081977 (Felis catus), 110784 (Mus musculus), 25672 (Rattus norvegicus)
4306 (Homo sapiens), 475461 (Canis lupus familiaris), 537614 (Bos taurus), 704789 (Macaca mulatta)
|
| Target Alternative Names |
NR3C2,Nr3c2,MR,Mlr,MCR,MLR,NR3C2VIT
|
| Uniprot Accession |
Q8VII8,P22199,P08235
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Aldosterone-regulated sodium reabsorption
|
| Gene Ensembl |
ENSECAG00000016605, ENSMUSG00000031618, ENSG00000151623, ENSCAFG00845013694, ENSBTAG00000027182, ENSMMUG00000014955
|
| Target Classification |
Nuclear Receptors, Tumor-associated antigen (TAA)
|
NR3C2/MR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4306 | Pre-made Human NR3C2/MR/MCR siRNA oligo Duplex | 4306 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25672 | Pre-made Rat Nr3c2/MCR/Mlr siRNA oligo Duplex | 25672 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo110784 | Pre-made Mouse Nr3c2/MR/Mlr siRNA oligo Duplex | 110784 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704789 | Pre-made Cynomolgus/Rhesus macaque NR3C2 siRNA oligo Duplex | 704789 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081977 | Pre-made Cat/Feline NR3C2 siRNA oligo Duplex | 101081977 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475461 | Pre-made Dog/Canine NR3C2 siRNA oligo Duplex | 475461 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537614 | Pre-made Bovines/Cattle NR3C2 siRNA oligo Duplex | 537614 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062570 | Pre-made Equine/Horse NR3C2 siRNA oligo Duplex | 100062570 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NR3C2/MR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T72168-Ab | Human | Anti-Human NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T72168-Ab | Rat | Anti-Rat NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T72168-Ab | Mouse | Anti-Mouse NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T72168-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T72168-Ab | Cat/Feline | Anti-Cat/Feline NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T72168-Ab | Dog/Canine | Anti-Dog/Canine NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T72168-Ab | Bovines/Cattle | Anti-Bovines/Cattle NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T72168-Ab | Equine/Horse | Anti-Equine/Horse NR3C2/MR monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NR3C2/MR recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T72168-Ag | Human | Human NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T72168-Ag | Rat | Rat NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T72168-Ag | Mouse | Mouse NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T72168-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T72168-Ag | Cat/Feline | Cat/Feline NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T72168-Ag | Dog/Canine | Dog/Canine NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T72168-Ag | Bovines/Cattle | Bovines/Cattle NR3C2/MR recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T72168-Ag | Equine/Horse | Equine/Horse NR3C2/MR recombinant protein | Mammalian cell | Detail |
