Explore UTRN gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T72120
|
| Target Name |
UTRN
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7402
|
| Gene ID |
100066683 (Equus caballus), 101096570 (Felis catus), 22288 (Mus musculus), 25600 (Rattus norvegicus)
442965 (Canis lupus familiaris), 534358 (Bos taurus), 699498 (Macaca mulatta), 7402 (Homo sapiens)
|
| Target Alternative Names |
DMDL,DRP,DRP-1,DRP1,Dmdl,Dystrophin-related protein 1 (DRP-1),UTRN,Utrn,Utrophin
|
| Uniprot Accession |
G3V7L1,P46939
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000019458, ENSMUSG00000019820, ENSCAFG00845012944, ENSBTAG00000009665, ENSMMUG00000019438, ENSG00000152818
|
UTRN siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7402 | Pre-made Human UTRN/DRP/DMDL siRNA oligo Duplex | 7402 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25600 | Pre-made Rat Utrn/DRP-1 siRNA oligo Duplex | 25600 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22288 | Pre-made Mouse Utrn/DRP/Dmdl siRNA oligo Duplex | 22288 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699498 | Pre-made Cynomolgus/Rhesus macaque UTRN siRNA oligo Duplex | 699498 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096570 | Pre-made Cat/Feline UTRN siRNA oligo Duplex | 101096570 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442965 | Pre-made Dog/Canine UTRN siRNA oligo Duplex | 442965 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534358 | Pre-made Bovines/Cattle UTRN siRNA oligo Duplex | 534358 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066683 | Pre-made Equine/Horse UTRN siRNA oligo Duplex | 100066683 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
UTRN antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T72120-Ab | Human | Anti-Human UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T72120-Ab | Rat | Anti-Rat UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T72120-Ab | Mouse | Anti-Mouse UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T72120-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T72120-Ab | Cat/Feline | Anti-Cat/Feline UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T72120-Ab | Dog/Canine | Anti-Dog/Canine UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T72120-Ab | Bovines/Cattle | Anti-Bovines/Cattle UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T72120-Ab | Equine/Horse | Anti-Equine/Horse UTRN monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
UTRN VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T72120-Ag | Human | Human UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T72120-Ag | Rat | Rat UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T72120-Ag | Mouse | Mouse UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T72120-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T72120-Ag | Cat/Feline | Cat/Feline UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T72120-Ag | Dog/Canine | Dog/Canine UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T72120-Ag | Bovines/Cattle | Bovines/Cattle UTRN VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T72120-Ag | Equine/Horse | Equine/Horse UTRN VLP (virus-like particle) | HEK293 | Products Developing |
