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Target
sublocation: Transmembrane Protein.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T71928
|
| Target Name |
KIR2DL1/CD158a/CD158A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3802
|
| Gene ID |
3802 (Homo sapiens)
|
| Target Alternative Names |
CD158 antigen-like family member A,CD158A,CD158a,KIR-K64,KIR221,KIR2DL1,KIR2DL3,Killer cell immunoglobulin-like receptor 2DL1,NKAT,NKAT-1,NKAT1,Natural killer-associated transcript 1 (NKAT-1),p58 natural killer cell receptor clones CL-42/47.11 (p58 NK receptor CL-42/47.11),p58.1,p58.1 MHC class-I-specific NK receptor
|
| Uniprot Accession |
P43626
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease from KEGG |
Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Graft-versus-host disease
|
| Gene Ensembl |
ENSG00000125498
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of KIR2DL1/CD158a/CD158A cDNA Clones/ORF Plasmid
KIR2DL1/CD158a/CD158A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3802 | Pre-made Human KIR2DL1/NKAT/NKAT1 siRNA oligo Duplex | 3802 | Human | In-vitro grade; in-vivo grade | Detail |
KIR2DL1/CD158a/CD158A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T71928-Ab | Human | Anti-Human KIR2DL1/CD158a/CD158A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KIR2DL1/CD158a/CD158A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T71928-Ag | Human | Human KIR2DL1/CD158a/CD158A VLP (virus-like particle) | HEK293 | Products Developing |
