Explore PLK4 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
| Target ID |
GM-T71374
|
| Target Name |
PLK4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10733
|
| Gene ID |
100063593 (Equus caballus), 101086791 (Felis catus), 10733 (Homo sapiens), 20873 (Mus musculus)
310344 (Rattus norvegicus), 476087 (Canis lupus familiaris), 514405 (Bos taurus), 710233 (Macaca mulatta)
|
| Target Alternative Names |
1700028H20,MCCRP2,PLK-4,PLK4,Plk4,Polo-like kinase 4 (PLK-4),SAK,STK18,Sak,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase PLK4,Serine/threonine-protein kinase Sak,Stk18
|
| Uniprot Accession |
O00444,Q64702,B2GUY1,A2VDZ4
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
FoxO signaling pathway
|
| Gene Ensembl |
ENSECAG00000008187, ENSG00000142731, ENSMUSG00000025758, ENSCAFG00845026928, ENSBTAG00000039552, ENSMMUG00000003320
|
| Target Classification |
Kinase
|
Pre-made viral vector of PLK4 cDNA Clones/ORF Plasmid
PLK4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10733 | Pre-made Human PLK4/SAK/STK18 siRNA oligo Duplex | 10733 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo310344 | Pre-made Rat Plk4 siRNA oligo Duplex | 310344 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20873 | Pre-made Mouse Plk4/Sak/Stk18 siRNA oligo Duplex | 20873 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710233 | Pre-made Cynomolgus/Rhesus macaque PLK4 siRNA oligo Duplex | 710233 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086791 | Pre-made Cat/Feline PLK4 siRNA oligo Duplex | 101086791 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476087 | Pre-made Dog/Canine PLK4 siRNA oligo Duplex | 476087 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514405 | Pre-made Bovines/Cattle PLK4/PLK-4 siRNA oligo Duplex | 514405 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063593 | Pre-made Equine/Horse PLK4 siRNA oligo Duplex | 100063593 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PLK4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T71374-Ab | Human | Anti-Human PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T71374-Ab | Rat | Anti-Rat PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T71374-Ab | Mouse | Anti-Mouse PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T71374-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T71374-Ab | Cat/Feline | Anti-Cat/Feline PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T71374-Ab | Dog/Canine | Anti-Dog/Canine PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T71374-Ab | Bovines/Cattle | Anti-Bovines/Cattle PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T71374-Ab | Equine/Horse | Anti-Equine/Horse PLK4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PLK4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T71374-Ag | Human | Human PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T71374-Ag | Rat | Rat PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T71374-Ag | Mouse | Mouse PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T71374-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T71374-Ag | Cat/Feline | Cat/Feline PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T71374-Ag | Dog/Canine | Dog/Canine PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T71374-Ag | Bovines/Cattle | Bovines/Cattle PLK4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T71374-Ag | Equine/Horse | Equine/Horse PLK4 recombinant protein | Mammalian cell | Detail |
