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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T71367
|
| Target Name |
MAP4K4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9448
|
| Gene ID |
100058919 (Equus caballus), 101081214 (Felis catus), 26921 (Mus musculus), 301363 (Rattus norvegicus)
481331 (Canis lupus familiaris), 509109 (Bos taurus), 716595 (Macaca mulatta), 9448 (Homo sapiens)
|
| Target Alternative Names |
9430080K19Rik,FLH21957,HEL-S-31,HGK,HPK/GCK-like kinase HGK,MAP4K4,MAPK/ERK kinase kinase kinase 4 (MEK kinase kinase 4,MEKKK 4),MEKKK4,Map4k4,Mitogen-activated protein kinase kinase kinase kinase 4,NIK,Nck-interacting kinase,Nik
|
| Uniprot Accession |
P97820,O95819
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
MAPK signaling pathway
|
| Gene Ensembl |
ENSECAG00000008730, ENSMUSG00000026074, ENSCAFG00845011330, ENSBTAG00000013023, ENSMMUG00000010811, ENSG00000071054
|
| Target Classification |
Checkpoint-Immuno Oncology, Kinase
|
Pre-made viral vector of MAP4K4 cDNA Clones/ORF Plasmid
MAP4K4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9448 | Pre-made Human MAP4K4/HGK/NIK siRNA oligo Duplex | 9448 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo301363 | Pre-made Rat Map4k4 siRNA oligo Duplex | 301363 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26921 | Pre-made Mouse Map4k4/HGK/Nik siRNA oligo Duplex | 26921 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716595 | Pre-made Cynomolgus/Rhesus macaque MAP4K4 siRNA oligo Duplex | 716595 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081214 | Pre-made Cat/Feline MAP4K4 siRNA oligo Duplex | 101081214 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481331 | Pre-made Dog/Canine MAP4K4 siRNA oligo Duplex | 481331 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509109 | Pre-made Bovines/Cattle MAP4K4 siRNA oligo Duplex | 509109 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058919 | Pre-made Equine/Horse MAP4K4 siRNA oligo Duplex | 100058919 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MAP4K4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T71367-Ab | Human | Anti-Human MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T71367-Ab | Rat | Anti-Rat MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T71367-Ab | Mouse | Anti-Mouse MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T71367-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T71367-Ab | Cat/Feline | Anti-Cat/Feline MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T71367-Ab | Dog/Canine | Anti-Dog/Canine MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T71367-Ab | Bovines/Cattle | Anti-Bovines/Cattle MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T71367-Ab | Equine/Horse | Anti-Equine/Horse MAP4K4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MAP4K4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T71367-Ag | Human | Human MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T71367-Ag | Rat | Rat MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T71367-Ag | Mouse | Mouse MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T71367-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T71367-Ag | Cat/Feline | Cat/Feline MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T71367-Ag | Dog/Canine | Dog/Canine MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T71367-Ag | Bovines/Cattle | Bovines/Cattle MAP4K4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T71367-Ag | Equine/Horse | Equine/Horse MAP4K4 recombinant protein | Mammalian cell | Detail |
