Explore CHRNA4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
| Target ID |
GM-T70967
|
| Target Name |
CHRNA4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1137
|
| Gene ID |
100146784 (Equus caballus), 101101300 (Felis catus), 1137 (Homo sapiens), 11438 (Mus musculus)
114670571 (Macaca mulatta), 25590 (Rattus norvegicus), 485972 (Canis lupus familiaris), 537251 (Bos taurus)
|
| Target Alternative Names |
Acra-4,Acra4,BFNC,CHRNA4,Chrna4,EBN,EBN1,ENFL1,NACHR,NACHRA4,NACRA4,NARAC,Neuronal acetylcholine receptor subunit alpha-4
|
| Uniprot Accession |
P43681,O70174,P09483
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Cholinergic synapse, Nicotine addiction, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSG00000101204, ENSMUSG00000027577, ENSMMUG00000015916, ENSCAFG00845020832, ENSBTAG00000017198
|
| Target Classification |
Ion Channel
|
Pre-made viral vector of CHRNA4 cDNA Clones/ORF Plasmid
CHRNA4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1137 | Pre-made Human CHRNA4/EBN/BFNC siRNA oligo Duplex | 1137 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25590 | Pre-made Rat Chrna4/NARAC siRNA oligo Duplex | 25590 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11438 | Pre-made Mouse Chrna4/EBN1/Acra4 siRNA oligo Duplex | 11438 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114670571 | Pre-made Cynomolgus/Rhesus macaque CHRNA4 siRNA oligo Duplex | 114670571 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101300 | Pre-made Cat/Feline CHRNA4 siRNA oligo Duplex | 101101300 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485972 | Pre-made Dog/Canine CHRNA4 siRNA oligo Duplex | 485972 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537251 | Pre-made Bovines/Cattle CHRNA4 siRNA oligo Duplex | 537251 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146784 | Pre-made Equine/Horse CHRNA4 siRNA oligo Duplex | 100146784 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHRNA4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T70967-Ab | Human | Anti-Human CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T70967-Ab | Rat | Anti-Rat CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T70967-Ab | Mouse | Anti-Mouse CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T70967-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T70967-Ab | Cat/Feline | Anti-Cat/Feline CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T70967-Ab | Dog/Canine | Anti-Dog/Canine CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T70967-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T70967-Ab | Equine/Horse | Anti-Equine/Horse CHRNA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CHRNA4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T70967-Ag | Human | Human CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T70967-Ag | Rat | Rat CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T70967-Ag | Mouse | Mouse CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T70967-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T70967-Ag | Cat/Feline | Cat/Feline CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T70967-Ag | Dog/Canine | Dog/Canine CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T70967-Ag | Bovines/Cattle | Bovines/Cattle CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T70967-Ag | Equine/Horse | Equine/Horse CHRNA4 VLP (virus-like particle) | HEK293 | Products Developing |
