Explore DR5/TNFRSF10B/CD262/TRAIL-R2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
| Target ID |
GM-T70067
|
| Target Name |
DR5/TNFRSF10B/CD262/TRAIL-R2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8795
|
| Gene ID |
21933 (Mus musculus), 364420 (Rattus norvegicus), 716650 (Macaca mulatta), 8795 (Homo sapiens)
|
| Target Alternative Names |
CD262,DR5,Death receptor 5,KILLER,KILLER/DR5,Ly98,MK,TNF-related apoptosis-inducing ligand receptor 2 (TRAIL receptor 2,TNFRSF10B,TRAIL-R2,TRAIL-R2),TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,Tnfrsf10b,Tumor necrosis factor receptor superfamily member 10B,ZTNFR9
|
| Uniprot Accession |
Q9QZM4,O14763
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, p53 signaling pathway, Apoptosis, Natural killer cell mediated cytotoxicity, Pathogenic Escherichia coli infection, Influenza A, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSMUSG00000022074, ENSMMUG00000048076, ENSG00000120889
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of DR5/TNFRSF10B/CD262/TRAIL-R2 cDNA Clones/ORF Plasmid
DR5/TNFRSF10B/CD262/TRAIL-R2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8795 | Pre-made Human TNFRSF10B/DR5/CD262 siRNA oligo Duplex | 8795 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo364420 | Pre-made Rat Tnfrsf10b siRNA oligo Duplex | 364420 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21933 | Pre-made Mouse Tnfrsf10b/MK/DR5 siRNA oligo Duplex | 21933 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716650 | Pre-made Cynomolgus/Rhesus macaque TNFRSF10B siRNA oligo Duplex | 716650 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
DR5/TNFRSF10B/CD262/TRAIL-R2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T70067-Ab | Human | Anti-Human DR5/TNFRSF10B/CD262/TRAIL-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T70067-Ab | Rat | Anti-Rat DR5/TNFRSF10B/CD262/TRAIL-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T70067-Ab | Mouse | Anti-Mouse DR5/TNFRSF10B/CD262/TRAIL-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T70067-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DR5/TNFRSF10B/CD262/TRAIL-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
DR5/TNFRSF10B/CD262/TRAIL-R2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T70067-Ag | Human | Human DR5/TNFRSF10B/CD262/TRAIL-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T70067-Ag | Rat | Rat DR5/TNFRSF10B/CD262/TRAIL-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T70067-Ag | Mouse | Mouse DR5/TNFRSF10B/CD262/TRAIL-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T70067-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DR5/TNFRSF10B/CD262/TRAIL-R2 VLP (virus-like particle) | HEK293 | Products Developing |
