Explore PTH1R gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
| Target ID |
GM-T67710
|
| Target Name |
PTH1R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5745
|
| Gene ID |
100054278 (Equus caballus), 101095960 (Felis catus), 19228 (Mus musculus), 403779 (Canis lupus familiaris)
507783 (Bos taurus), 56813 (Rattus norvegicus), 5745 (Homo sapiens), 712147 (Macaca mulatta)
|
| Target Alternative Names |
EKNS,PFE,PPR,PTH/PTHrP type I receptor (PTH/PTHr receptor),PTH1,PTH1R,PTHR,PTHR1,PTHrel,Parathyroid hormone 1 receptor (PTH1 receptor),Parathyroid hormone/parathyroid hormone-related peptide receptor,Pth1r,Pthr,Pthr1
|
| Uniprot Accession |
P41593,Q9TU31,Q1LZF7,P25961,Q03431
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action
|
| Gene Ensembl |
ENSECAG00000008888, ENSMUSG00000032492, ENSCAFG00845010997, ENSBTAG00000016948, ENSG00000160801, ENSMMUG00000014742
|
| Target Classification |
GPCR
|
Pre-made viral vector of PTH1R cDNA Clones/ORF Plasmid
PTH1R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5745 | Pre-made Human PTH1R/PFE/EKNS siRNA oligo Duplex | 5745 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56813 | Pre-made Rat Pth1r/Pthr/Pthr1 siRNA oligo Duplex | 56813 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19228 | Pre-made Mouse Pth1r/PPR/Pthr siRNA oligo Duplex | 19228 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712147 | Pre-made Cynomolgus/Rhesus macaque PTH1R/PTHR1 siRNA oligo Duplex | 712147 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095960 | Pre-made Cat/Feline PTH1R siRNA oligo Duplex | 101095960 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403779 | Pre-made Dog/Canine PTH1R/PTH1/PTHR1 siRNA oligo Duplex | 403779 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507783 | Pre-made Bovines/Cattle PTH1R/PTHR1 siRNA oligo Duplex | 507783 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054278 | Pre-made Equine/Horse PTH1R siRNA oligo Duplex | 100054278 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTH1R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T67710-Ab | Human | Anti-Human PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T67710-Ab | Rat | Anti-Rat PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T67710-Ab | Mouse | Anti-Mouse PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T67710-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T67710-Ab | Cat/Feline | Anti-Cat/Feline PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T67710-Ab | Dog/Canine | Anti-Dog/Canine PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T67710-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T67710-Ab | Equine/Horse | Anti-Equine/Horse PTH1R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PTH1R VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T67710-Ag | Human | Human PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T67710-Ag | Rat | Rat PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T67710-Ag | Mouse | Mouse PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T67710-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T67710-Ag | Cat/Feline | Cat/Feline PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T67710-Ag | Dog/Canine | Dog/Canine PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T67710-Ag | Bovines/Cattle | Bovines/Cattle PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T67710-Ag | Equine/Horse | Equine/Horse PTH1R VLP (virus-like particle) | HEK293 | Products Developing |
