Explore CHRM3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
| Target ID |
GM-T67684
|
| Target Name |
CHRM3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1131
|
| Gene ID |
100056633 (Equus caballus), 101100919 (Felis catus), 1131 (Homo sapiens), 12671 (Mus musculus)
24260 (Rattus norvegicus), 281685 (Bos taurus), 403827 (Canis lupus familiaris), 708901 (Macaca mulatta)
|
| Target Alternative Names |
CHRM3,Chrm-3,Chrm3,EGBRS,HM3,M3,M3R,Muscarinic acetylcholine receptor M3,PBS,m3AChR
|
| Uniprot Accession |
P20309,Q9ERZ3,P08483,P41984
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000010286, ENSG00000133019, ENSMUSG00000046159, ENSBTAG00000008059, ENSCAFG00845002175, ENSMMUG00000021442
|
| Target Classification |
GPCR
|
Pre-made viral vector of CHRM3 cDNA Clones/ORF Plasmid
CHRM3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1131 | Pre-made Human CHRM3/HM3/PBS siRNA oligo Duplex | 1131 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24260 | Pre-made Rat Chrm3 siRNA oligo Duplex | 24260 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12671 | Pre-made Mouse Chrm3/M3/M3R siRNA oligo Duplex | 12671 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708901 | Pre-made Cynomolgus/Rhesus macaque CHRM3 siRNA oligo Duplex | 708901 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100919 | Pre-made Cat/Feline CHRM3 siRNA oligo Duplex | 101100919 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403827 | Pre-made Dog/Canine CHRM3 siRNA oligo Duplex | 403827 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281685 | Pre-made Bovines/Cattle CHRM3 siRNA oligo Duplex | 281685 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056633 | Pre-made Equine/Horse CHRM3 siRNA oligo Duplex | 100056633 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHRM3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T67684-Ab | Human | Anti-Human CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T67684-Ab | Rat | Anti-Rat CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T67684-Ab | Mouse | Anti-Mouse CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T67684-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T67684-Ab | Cat/Feline | Anti-Cat/Feline CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T67684-Ab | Dog/Canine | Anti-Dog/Canine CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T67684-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T67684-Ab | Equine/Horse | Anti-Equine/Horse CHRM3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CHRM3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T67684-Ag | Human | Human CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T67684-Ag | Rat | Rat CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T67684-Ag | Mouse | Mouse CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T67684-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T67684-Ag | Cat/Feline | Cat/Feline CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T67684-Ag | Dog/Canine | Dog/Canine CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T67684-Ag | Bovines/Cattle | Bovines/Cattle CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T67684-Ag | Equine/Horse | Equine/Horse CHRM3 VLP (virus-like particle) | HEK293 | Products Developing |
