Explore FLNA gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
| Target ID |
GM-T66161
|
| Target Name |
FLNA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2316
|
| Gene ID |
100058256 (Equus caballus), 101082637 (Felis catus), 192176 (Mus musculus), 2316 (Homo sapiens)
281165 (Bos taurus), 293860 (Rattus norvegicus), 481084 (Canis lupus familiaris), 699524 (Macaca mulatta)
|
| Target Alternative Names |
ABP-280,ABPX,Actin-binding protein 280 (ABP-280),Alpha-filamin,CSBS,CVD1,Dilp2,Endothelial actin-binding protein,F730004A14Rik,FGS2,FLN,FLN-A,FLN1,FLNA,FMD,Filamin-1,Filamin-A,Fln1,Flna,GENA 379,MNS,NHBP,Non-muscle filamin,OPD,OPD1,OPD2,RGD1560614,XLVD,XMVD,filamin-1
|
| Uniprot Accession |
Q8BTM8,P21333
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Prostate Cancer
|
| Disease from KEGG |
MAPK signaling pathway, Focal adhesion, Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000009550, ENSMUSG00000031328, ENSG00000196924, ENSBTAG00000011190, ENSCAFG00845027901, ENSMMUG00000013668
|
FLNA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2316 | Pre-made Human FLNA/FLN/FMD siRNA oligo Duplex | 2316 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo293860 | Pre-made Rat Flna/RGD1560614 siRNA oligo Duplex | 293860 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo192176 | Pre-made Mouse Flna/Fln1/Dilp2 siRNA oligo Duplex | 192176 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699524 | Pre-made Cynomolgus/Rhesus macaque FLNA siRNA oligo Duplex | 699524 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082637 | Pre-made Cat/Feline FLNA siRNA oligo Duplex | 101082637 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481084 | Pre-made Dog/Canine FLNA siRNA oligo Duplex | 481084 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281165 | Pre-made Bovines/Cattle FLNA siRNA oligo Duplex | 281165 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058256 | Pre-made Equine/Horse FLNA siRNA oligo Duplex | 100058256 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FLNA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T66161-Ab | Human | Anti-Human FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T66161-Ab | Rat | Anti-Rat FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T66161-Ab | Mouse | Anti-Mouse FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T66161-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T66161-Ab | Cat/Feline | Anti-Cat/Feline FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T66161-Ab | Dog/Canine | Anti-Dog/Canine FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T66161-Ab | Bovines/Cattle | Anti-Bovines/Cattle FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T66161-Ab | Equine/Horse | Anti-Equine/Horse FLNA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
FLNA VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T66161-Ag | Human | Human FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T66161-Ag | Rat | Rat FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T66161-Ag | Mouse | Mouse FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T66161-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T66161-Ag | Cat/Feline | Cat/Feline FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T66161-Ag | Dog/Canine | Dog/Canine FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T66161-Ag | Bovines/Cattle | Bovines/Cattle FLNA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T66161-Ag | Equine/Horse | Equine/Horse FLNA VLP (virus-like particle) | HEK293 | Products Developing |
