Explore GPER1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T65236
|
| Target Name |
GPER1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2852
|
| Gene ID |
101085767 (Felis catus), 102148430 (Equus caballus), 171104 (Rattus norvegicus), 2852 (Homo sapiens) 480808 (Canis lupus familiaris), 527831 (Bos taurus), 696625 (Macaca mulatta), 76854 (Mus musculus)
|
| Target Alternative Names |
6330420K13Rik,CEPR,CMKRL2,Ceprl,Chemoattractant receptor-like 2,DRY12,FEG-1,Flow-induced endothelial G-protein coupled receptor 1 (FEG-1),G protein-coupled estrogen receptor 1,G-protein coupled estrogen receptor 1,G-protein coupled receptor 30,GPCR-Br,GPER,GPER1,GPR30,GPR41,Gper,Gper1,Gpr30,IL8-related receptor DRY12,LERGU,LERGU2,LyGPR,Lymphocyte-derived G-protein coupled receptor (LYGPR),Membrane estrogen receptor (mER),mER
|
| Uniprot Accession |
O08878,Q99527,F7EQ49,Q8BMP4
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Endocrine resistance, GnRH secretion
|
| Gene Ensembl |
ENSECAG00000001177, ENSG00000164850, ENSCAFG00845008614, ENSBTAG00000060277, ENSMMUG00000007209, ENSMUSG00000053647
|
| Target Classification |
GPCR, Tumor-associated antigen (TAA)
|
Pre-made viral vector of GPER1 cDNA Clones/ORF Plasmid
GPER1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2852 | Pre-made Human GPER1/mER/CEPR siRNA oligo Duplex | 2852 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171104 | Pre-made Rat Gper1/Gper/GPR41 siRNA oligo Duplex | 171104 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo76854 | Pre-made Mouse Gper1/Gper/Ceprl siRNA oligo Duplex | 76854 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696625 | Pre-made Cynomolgus/Rhesus macaque GPER1/GPER/GPR30 siRNA oligo Duplex | 696625 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085767 | Pre-made Cat/Feline GPER1/GPER siRNA oligo Duplex | 101085767 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480808 | Pre-made Dog/Canine GPER1/GPER/GPR30 siRNA oligo Duplex | 480808 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo527831 | Pre-made Bovines/Cattle GPER1/GPER siRNA oligo Duplex | 527831 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102148430 | Pre-made Equine/Horse GPER1 siRNA oligo Duplex | 102148430 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GPER1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T65236-Ab | Human | Anti-Human GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T65236-Ab | Rat | Anti-Rat GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T65236-Ab | Mouse | Anti-Mouse GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T65236-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T65236-Ab | Cat/Feline | Anti-Cat/Feline GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T65236-Ab | Dog/Canine | Anti-Dog/Canine GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T65236-Ab | Bovines/Cattle | Anti-Bovines/Cattle GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T65236-Ab | Equine/Horse | Anti-Equine/Horse GPER1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GPER1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T65236-Ag | Human | Human GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T65236-Ag | Rat | Rat GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T65236-Ag | Mouse | Mouse GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T65236-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T65236-Ag | Cat/Feline | Cat/Feline GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T65236-Ag | Dog/Canine | Dog/Canine GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T65236-Ag | Bovines/Cattle | Bovines/Cattle GPER1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T65236-Ag | Equine/Horse | Equine/Horse GPER1 VLP (virus-like particle) | HEK293 | Products Developing |