Explore P2RX7 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
| Target ID |
GM-T63414
|
| Target Name |
P2RX7
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5027
|
| Gene ID |
100058464 (Equus caballus), 101097922 (Felis catus), 18439 (Mus musculus), 286814 (Bos taurus)
29665 (Rattus norvegicus), 448778 (Canis lupus familiaris), 5027 (Homo sapiens), 699455 (Macaca mulatta)
|
| Target Alternative Names |
ATP receptor,P2RX7,P2X purinoceptor 7,P2X(7),P2X7,P2X7R,P2Z receptor,P2rx7,Purinergic receptor
|
| Uniprot Accession |
Q9Z1M0,Q64663,Q99572
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Calcium signaling pathway, Neuroactive ligand-receptor interaction, NOD-like receptor signaling pathway
|
| Gene Ensembl |
ENSECAG00000009949, ENSMUSG00000029468, ENSBTAG00000008948, ENSCAFG00845027103, ENSG00000089041, ENSMMUG00000006298
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of P2RX7 cDNA Clones/ORF Plasmid
P2RX7 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5027 | Pre-made Human P2RX7/P2X7 siRNA oligo Duplex | 5027 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29665 | Pre-made Rat P2rx7 siRNA oligo Duplex | 29665 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18439 | Pre-made Mouse P2rx7/P2X7R/P2X(7) siRNA oligo Duplex | 18439 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699455 | Pre-made Cynomolgus/Rhesus macaque P2RX7 siRNA oligo Duplex | 699455 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097922 | Pre-made Cat/Feline P2RX7 siRNA oligo Duplex | 101097922 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo448778 | Pre-made Dog/Canine P2RX7/P2X7 siRNA oligo Duplex | 448778 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo286814 | Pre-made Bovines/Cattle P2RX7 siRNA oligo Duplex | 286814 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058464 | Pre-made Equine/Horse P2RX7 siRNA oligo Duplex | 100058464 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
P2RX7 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T63414-Ab | Human | Anti-Human P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T63414-Ab | Rat | Anti-Rat P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T63414-Ab | Mouse | Anti-Mouse P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T63414-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T63414-Ab | Cat/Feline | Anti-Cat/Feline P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T63414-Ab | Dog/Canine | Anti-Dog/Canine P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T63414-Ab | Bovines/Cattle | Anti-Bovines/Cattle P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T63414-Ab | Equine/Horse | Anti-Equine/Horse P2RX7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
P2RX7 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T63414-Ag | Human | Human P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T63414-Ag | Rat | Rat P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T63414-Ag | Mouse | Mouse P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T63414-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T63414-Ag | Cat/Feline | Cat/Feline P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T63414-Ag | Dog/Canine | Dog/Canine P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T63414-Ag | Bovines/Cattle | Bovines/Cattle P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T63414-Ag | Equine/Horse | Equine/Horse P2RX7 VLP (virus-like particle) | HEK293 | Products Developing |
