Explore MRP2/ABCC2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T61792
|
| Target Name |
MRP2/ABCC2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1244
|
| Gene ID |
100060654 (Equus caballus), 101085924 (Felis catus), 1244 (Homo sapiens), 12780 (Mus musculus)
25303 (Rattus norvegicus), 403632 (Canis lupus familiaris), 520925 (Bos taurus), 574169 (Macaca mulatta)
|
| Target Alternative Names |
ABC30,ABCC2,ATP-binding cassette sub-family C member 2,Abc30,Abcc2,CMOAT,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,Cmoat,DJS,MRP2,Mrp2,Multidrug resistance-associated protein 2,cMRP,mrp,mrp2
|
| Uniprot Accession |
Q92887,Q8VI47,Q63120
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Antifolate resistance, ABC transporters, Bile secretion
|
| Gene Ensembl |
ENSECAG00000019828, ENSG00000023839, ENSMUSG00000025194, ENSCAFG00845030901, ENSBTAG00000008936, ENSMMUG00000023764
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of MRP2/ABCC2 cDNA Clones/ORF Plasmid
MRP2/ABCC2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1244 | Pre-made Human ABCC2/DJS/MRP2 siRNA oligo Duplex | 1244 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25303 | Pre-made Rat Abcc2/mrp/Mrp2 siRNA oligo Duplex | 25303 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12780 | Pre-made Mouse Abcc2/Mrp2/cMRP siRNA oligo Duplex | 12780 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574169 | Pre-made Cynomolgus/Rhesus macaque ABCC2/mrp2 siRNA oligo Duplex | 574169 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085924 | Pre-made Cat/Feline ABCC2 siRNA oligo Duplex | 101085924 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403632 | Pre-made Dog/Canine ABCC2/MRP2 siRNA oligo Duplex | 403632 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo520925 | Pre-made Bovines/Cattle ABCC2 siRNA oligo Duplex | 520925 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060654 | Pre-made Equine/Horse ABCC2/MRP2 siRNA oligo Duplex | 100060654 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MRP2/ABCC2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T61792-Ab | Human | Anti-Human MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T61792-Ab | Rat | Anti-Rat MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T61792-Ab | Mouse | Anti-Mouse MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T61792-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T61792-Ab | Cat/Feline | Anti-Cat/Feline MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T61792-Ab | Dog/Canine | Anti-Dog/Canine MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T61792-Ab | Bovines/Cattle | Anti-Bovines/Cattle MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T61792-Ab | Equine/Horse | Anti-Equine/Horse MRP2/ABCC2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MRP2/ABCC2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T61792-Ag | Human | Human MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T61792-Ag | Rat | Rat MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T61792-Ag | Mouse | Mouse MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T61792-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T61792-Ag | Cat/Feline | Cat/Feline MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T61792-Ag | Dog/Canine | Dog/Canine MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T61792-Ag | Bovines/Cattle | Bovines/Cattle MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T61792-Ag | Equine/Horse | Equine/Horse MRP2/ABCC2 VLP (virus-like particle) | HEK293 | Products Developing |
