Explore PDE4A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
| Target ID |
GM-T61744
|
| Target Name |
PDE4A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5141
|
| Gene ID |
100147080 (Equus caballus), 100683695 (Canis lupus familiaris), 18577 (Mus musculus), 25638 (Rattus norvegicus)
512222 (Bos taurus), 5141 (Homo sapiens), 712850 (Macaca mulatta), 751107 (Felis catus)
|
| Target Alternative Names |
3',5'-cyclic-AMP phosphodiesterase 4A,D9Ertd60e,DPDE2,Dpde2,PDE4,PDE46,PDE4A,PHOSA,Pde4a,cAMP-specific phosphodiesterase 4A
|
| Uniprot Accession |
O89084,P54748,P27815
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction
|
| Gene Ensembl |
ENSECAG00000023182, ENSCAFG00845026907, ENSMUSG00000032177, ENSBTAG00000012032, ENSG00000065989, ENSMMUG00000016122
|
PDE4A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5141 | Pre-made Human PDE4A/PDE4/DPDE2 siRNA oligo Duplex | 5141 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25638 | Pre-made Rat Pde4a/DPDE2/PHOSA siRNA oligo Duplex | 25638 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18577 | Pre-made Mouse Pde4a/Dpde2/D9Ertd60e siRNA oligo Duplex | 18577 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo712850 | Pre-made Cynomolgus/Rhesus macaque PDE4A siRNA oligo Duplex | 712850 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo751107 | Pre-made Cat/Feline PDE4A siRNA oligo Duplex | 751107 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100683695 | Pre-made Dog/Canine PDE4A siRNA oligo Duplex | 100683695 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512222 | Pre-made Bovines/Cattle PDE4A siRNA oligo Duplex | 512222 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147080 | Pre-made Equine/Horse PDE4A siRNA oligo Duplex | 100147080 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDE4A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T61744-Ab | Human | Anti-Human PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T61744-Ab | Rat | Anti-Rat PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T61744-Ab | Mouse | Anti-Mouse PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T61744-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T61744-Ab | Cat/Feline | Anti-Cat/Feline PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T61744-Ab | Dog/Canine | Anti-Dog/Canine PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T61744-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T61744-Ab | Equine/Horse | Anti-Equine/Horse PDE4A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PDE4A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T61744-Ag | Human | Human PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T61744-Ag | Rat | Rat PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T61744-Ag | Mouse | Mouse PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T61744-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T61744-Ag | Cat/Feline | Cat/Feline PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T61744-Ag | Dog/Canine | Dog/Canine PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T61744-Ag | Bovines/Cattle | Bovines/Cattle PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T61744-Ag | Equine/Horse | Equine/Horse PDE4A VLP (virus-like particle) | HEK293 | Products Developing |
