GRM7/mGluR7 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

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Target sublocation: Transmembrane Protein.
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Pre-made viral vector of GRM7/mGluR7 cDNA Clones/ORF Plasmid

GRM7/mGluR7 siRNA/miRNA/oligo for RNA interfence (RNAi)

GRM7/mGluR7 antibody/GMab

GRM7/mGluR7 VLP (virus-like particle)/protein