Explore PTP4A2/PRL-2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
| Target ID |
GM-T60897
|
| Target Name |
PTP4A2/PRL-2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8073
|
| Gene ID |
100056044 (Equus caballus), 101097001 (Felis catus), 19244 (Mus musculus), 609835 (Canis lupus familiaris)
614435 (Bos taurus), 706489 (Macaca mulatta), 8073 (Homo sapiens), 85237 (Rattus norvegicus)
|
| Target Alternative Names |
HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP(CAAXII),PTP4A,PTP4A2,PTP4A3,PTPCAAX2,Prl-2,Protein tyrosine phosphatase type IVA 2,Protein-tyrosine phosphatase 4a2,Protein-tyrosine phosphatase of regenerating liver 2 (PRL-2),Ptp4a2,ptp-IV1a,ptp-IV1b
|
| Uniprot Accession |
O70274,Q12974,Q6P9X4
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000005653, ENSMUSG00000028788, ENSCAFG00845005093, ENSBTAG00000039121, ENSMMUG00000046901, ENSG00000184007
|
| Target Classification |
|
PTP4A2/PRL-2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8073 | Pre-made Human PTP4A2/HH13/OV-1 siRNA oligo Duplex | 8073 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo85237 | Pre-made Rat Ptp4a2 siRNA oligo Duplex | 85237 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19244 | Pre-made Mouse Ptp4a2/Prl-2 siRNA oligo Duplex | 19244 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo706489 | Pre-made Cynomolgus/Rhesus macaque PTP4A2 siRNA oligo Duplex | 706489 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097001 | Pre-made Cat/Feline PTP4A2 siRNA oligo Duplex | 101097001 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609835 | Pre-made Dog/Canine PTP4A2 siRNA oligo Duplex | 609835 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo614435 | Pre-made Bovines/Cattle PTP4A2/PTP4A3 siRNA oligo Duplex | 614435 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056044 | Pre-made Equine/Horse PTP4A2 siRNA oligo Duplex | 100056044 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTP4A2/PRL-2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60897-Ab | Human | Anti-Human PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60897-Ab | Rat | Anti-Rat PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60897-Ab | Mouse | Anti-Mouse PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60897-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60897-Ab | Cat/Feline | Anti-Cat/Feline PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60897-Ab | Dog/Canine | Anti-Dog/Canine PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T60897-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60897-Ab | Equine/Horse | Anti-Equine/Horse PTP4A2/PRL-2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PTP4A2/PRL-2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60897-Ag | Human | Human PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T60897-Ag | Rat | Rat PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T60897-Ag | Mouse | Mouse PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T60897-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T60897-Ag | Cat/Feline | Cat/Feline PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T60897-Ag | Dog/Canine | Dog/Canine PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T60897-Ag | Bovines/Cattle | Bovines/Cattle PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T60897-Ag | Equine/Horse | Equine/Horse PTP4A2/PRL-2 recombinant protein | Mammalian cell | Detail |
