Explore OPRK1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
| Target ID |
GM-T60693
|
| Target Name |
OPRK1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4986
|
| Gene ID |
100054492 (Equus caballus), 101094729 (Felis catus), 18387 (Mus musculus), 29335 (Rattus norvegicus) 486951 (Canis lupus familiaris), 4986 (Homo sapiens), 540519 (Bos taurus), 710783 (Macaca mulatta)
|
| Target Alternative Names |
K-OR-1,KOP,KOR,KOR-1,KOR1,Kappa-type opioid receptor,MSL-1,OPRK,OPRK1,Oprk1,Oprk2,R21
|
| Uniprot Accession |
P33534,P34975,P41145,Q2KIP6
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction
|
| Gene Ensembl |
ENSECAG00000014442, ENSMUSG00000025905, ENSCAFG00845024764, ENSG00000082556, ENSBTAG00000000914, ENSMMUG00000065247
|
| Target Classification |
GPCR
|
Pre-made viral vector of OPRK1 cDNA Clones/ORF Plasmid
OPRK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4986 | Pre-made Human OPRK1/KOP/KOR siRNA oligo Duplex | 4986 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29335 | Pre-made Rat Oprk1 siRNA oligo Duplex | 29335 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18387 | Pre-made Mouse Oprk1/KOR/R21 siRNA oligo Duplex | 18387 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710783 | Pre-made Cynomolgus/Rhesus macaque OPRK1 siRNA oligo Duplex | 710783 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094729 | Pre-made Cat/Feline OPRK1 siRNA oligo Duplex | 101094729 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486951 | Pre-made Dog/Canine OPRK1 siRNA oligo Duplex | 486951 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540519 | Pre-made Bovines/Cattle OPRK1 siRNA oligo Duplex | 540519 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054492 | Pre-made Equine/Horse OPRK1 siRNA oligo Duplex | 100054492 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
OPRK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60693-Ab | Human | Anti-Human OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60693-Ab | Rat | Anti-Rat OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60693-Ab | Mouse | Anti-Mouse OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60693-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60693-Ab | Cat/Feline | Anti-Cat/Feline OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60693-Ab | Dog/Canine | Anti-Dog/Canine OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T60693-Ab | Bovines/Cattle | Anti-Bovines/Cattle OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60693-Ab | Equine/Horse | Anti-Equine/Horse OPRK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
OPRK1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60693-Ag | Human | Human OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T60693-Ag | Rat | Rat OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T60693-Ag | Mouse | Mouse OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T60693-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T60693-Ag | Cat/Feline | Cat/Feline OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T60693-Ag | Dog/Canine | Dog/Canine OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T60693-Ag | Bovines/Cattle | Bovines/Cattle OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T60693-Ag | Equine/Horse | Equine/Horse OPRK1 VLP (virus-like particle) | HEK293 | Products Developing |