Explore TSHR gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
| Target ID |
GM-T60606
|
| Target Name |
TSHR
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7253
|
| Gene ID |
100052603 (Equus caballus), 22095 (Mus musculus), 25360 (Rattus norvegicus), 281553 (Bos taurus)
403968 (Canis lupus familiaris), 493842 (Felis catus), 574251 (Macaca mulatta), 7253 (Homo sapiens)
|
| Target Alternative Names |
CHNG1,LGR3,TSH-R,TSHR,TSHRA,Thyroid-stimulating hormone receptor (TSH-R),Thyrotropin receptor,Tshr,hTSHR-I,hypothroid,hyt,pet
|
| Uniprot Accession |
P47750,P21463,Q27987,P14763,Q9BGN4,P16473
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease
|
| Gene Ensembl |
ENSECAG00000015397, ENSMUSG00000020963, ENSBTAG00000017489, ENSCAFG00845008943, ENSMMUG00000019713, ENSG00000165409
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of TSHR cDNA Clones/ORF Plasmid
TSHR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7253 | Pre-made Human TSHR/LGR3/CHNG1 siRNA oligo Duplex | 7253 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25360 | Pre-made Rat Tshr/TSHRA siRNA oligo Duplex | 25360 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22095 | Pre-made Mouse Tshr/hyt/pet siRNA oligo Duplex | 22095 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574251 | Pre-made Cynomolgus/Rhesus macaque TSHR siRNA oligo Duplex | 574251 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493842 | Pre-made Cat/Feline TSHR/TSH-R siRNA oligo Duplex | 493842 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403968 | Pre-made Dog/Canine TSHR siRNA oligo Duplex | 403968 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281553 | Pre-made Bovines/Cattle TSHR siRNA oligo Duplex | 281553 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052603 | Pre-made Equine/Horse TSHR siRNA oligo Duplex | 100052603 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TSHR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60606-Ab | Human | Anti-Human TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60606-Ab | Rat | Anti-Rat TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60606-Ab | Mouse | Anti-Mouse TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60606-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60606-Ab | Cat/Feline | Anti-Cat/Feline TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60606-Ab | Dog/Canine | Anti-Dog/Canine TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T60606-Ab | Bovines/Cattle | Anti-Bovines/Cattle TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60606-Ab | Equine/Horse | Anti-Equine/Horse TSHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TSHR VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60606-Ag | Human | Human TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T60606-Ag | Rat | Rat TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T60606-Ag | Mouse | Mouse TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T60606-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T60606-Ag | Cat/Feline | Cat/Feline TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T60606-Ag | Dog/Canine | Dog/Canine TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T60606-Ag | Bovines/Cattle | Bovines/Cattle TSHR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T60606-Ag | Equine/Horse | Equine/Horse TSHR VLP (virus-like particle) | HEK293 | Products Developing |
