Explore GPNMB gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T59856
|
| Target Name |
GPNMB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10457
|
| Gene ID |
100067870 (Equus caballus), 101090001 (Felis catus), 10457 (Homo sapiens), 113955 (Rattus norvegicus)
482355 (Canis lupus familiaris), 509600 (Bos taurus), 704990 (Macaca mulatta), 93695 (Mus musculus)
|
| Target Alternative Names |
DC-HIL,Dchil,GPNMB,Gpnmb,HGFIN,Hematopoietic growth factor inducible neurokinin-1 type,NMB,PLCA3,Transmembrane glycoprotein NMB,ipd
|
| Uniprot Accession |
Q14956,Q6P7C7,Q99P91
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
Prostate Cancer
|
| Gene Ensembl |
ENSECAG00000000658, ENSG00000136235, ENSBTAG00000000604, ENSMMUG00000012648, ENSMUSG00000029816
|
Pre-made viral vector of GPNMB cDNA Clones/ORF Plasmid
GPNMB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10457 | Pre-made Human GPNMB/NMB/HGFIN siRNA oligo Duplex | 10457 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo113955 | Pre-made Rat Gpnmb siRNA oligo Duplex | 113955 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo93695 | Pre-made Mouse Gpnmb/ipd/Dchil siRNA oligo Duplex | 93695 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704990 | Pre-made Cynomolgus/Rhesus macaque GPNMB siRNA oligo Duplex | 704990 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090001 | Pre-made Cat/Feline GPNMB siRNA oligo Duplex | 101090001 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482355 | Pre-made Dog/Canine GPNMB siRNA oligo Duplex | 482355 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo509600 | Pre-made Bovines/Cattle GPNMB siRNA oligo Duplex | 509600 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067870 | Pre-made Equine/Horse GPNMB siRNA oligo Duplex | 100067870 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GPNMB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59856-Ab | Human | Anti-Human GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T59856-Ab | Rat | Anti-Rat GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T59856-Ab | Mouse | Anti-Mouse GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T59856-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T59856-Ab | Cat/Feline | Anti-Cat/Feline GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T59856-Ab | Dog/Canine | Anti-Dog/Canine GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T59856-Ab | Bovines/Cattle | Anti-Bovines/Cattle GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T59856-Ab | Equine/Horse | Anti-Equine/Horse GPNMB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GPNMB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59856-Ag | Human | Human GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T59856-Ag | Rat | Rat GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T59856-Ag | Mouse | Mouse GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T59856-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59856-Ag | Cat/Feline | Cat/Feline GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T59856-Ag | Dog/Canine | Dog/Canine GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T59856-Ag | Bovines/Cattle | Bovines/Cattle GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T59856-Ag | Equine/Horse | Equine/Horse GPNMB VLP (virus-like particle) | HEK293 | Products Developing |
