EGFR Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
| Target ID | GM-T59328 |
| Target Name | EGFR |
|
Gene Group ldentifer （Target Gene ID in Homo species) |
1956 |
| Gene ID |
100067755 (Equus caballus), 100510799 (Felis catus), 13649 (Mus musculus), 1956 (Homo sapiens) 24329 (Rattus norvegicus), 404306 (Canis lupus familiaris), 407217 (Bos taurus), 613027 (Macaca mulatta) |
| Target Alternative Names | 9030024J15Rik,EGFR,ERBB,ERBB1,ERRP,Egfr,Epidermal growth factor receptor,ErbB-1,Erbb,Errb1,Errp,HER1,NISBD2,NNCIS,PIG61,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,Wa5,mENA,wa-2,wa2 |
| Uniprot Accession | Q01279,P00533,P55245 |
| Uniprot Entry Name | |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | cancer, Breast Cancer, Non-Small Cell Lung Cancer, Breast Cancer, gastric cancer, apoptosis, Asphyxia neonatorum, Urinary bladder urothelial carcinoma |
| Disease from KEGG | EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer |
| Gene Ensembl | ENSECAG00000009952, ENSMUSG00000020122, ENSG00000146648, ENSCAFG00845011396, ENSBTAG00000011628, ENSMMUG00000022394 |
| Target Classification | Cytokine Receptor, Kinase, Checkpoint-Immuno Oncology |
Pre-made viral vector of EGFR cDNA Clones/ORF Plasmid
| Cat No. | Product Name | NMID | GeneID | Species | Type | Marker | Fusion Tag | Promoter | Detail |
|---|---|---|---|---|---|---|---|---|---|
| pGMLP005677 | Human EGFR/ERBB/ERBB1 Lentivirus plasmid | NM_005228.4 | 1956 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV000216 | Human EGFR/ERBB/ERBB1 Lentivirus plasmid | NM_005228.4 | 1956 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV000217 | Human EGFR/ERBB/ERBB1 Lentivirus plasmid | NM_005228.3 | 1956 | Human | Lentivirus plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| pGMLV000508 | Human EGFR/ERBB/ERBB1 Lentivirus plasmid | NM_005228.4 | 1956 | Human | Lentivirus plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMAD000182 | Human EGFR/ERBB/ERBB1 Adenovirus plasmid | NM_005228.3 | 1956 | Human | Adenovirus plasmid | Null | 3xflag (C-Terminal) | CMV | Detail |
| pGMPC000460 | Human EGFR/ERBB/ERBB1 Mammalian (Non-Viral Vector) plasmid | NM_005228 | 1956 | Human | Mammalian (Non-Viral Vector) plasmid | EGFP | 3xflag (C-Terminal) | EF1 | Detail |
| pGMPC001179 | Human EGFR/ERBB/ERBB1 Mammalian (Non-Viral Vector) plasmid | NM_005228.4 | 1956 | Human | Mammalian (Non-Viral Vector) plasmid | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLP005677 | Human EGFR/ERBB/ERBB1 Lentivirus particle | NM_005228.4 | 1956 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV000216 | Human EGFR/ERBB/ERBB1 Lentivirus particle | NM_005228.4 | 1956 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV000217 | Human EGFR/ERBB/ERBB1 Lentivirus particle | NM_005228.3 | 1956 | Human | Lentivirus particle | ZsGreen | 3xflag (C-Terminal) | CMV | Detail |
| vGMLV000508 | Human EGFR/ERBB/ERBB1 Lentivirus particle | NM_005228.4 | 1956 | Human | Lentivirus particle | Null | 3xflag (C-Terminal) | CMV | Detail |
| vGMAD000182 | Human EGFR/ERBB/ERBB1 Adenovirus particle | NM_005228.3 | 1956 | Human | Adenovirus particle | Null | 3xflag (C-Terminal) | CMV | Detail |
EGFR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|---|---|---|---|---|
| pGMoligo1956 | Pre-made Human EGFR/ERBB/ERRP siRNA oligo Duplex | 1956 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24329 | Pre-made Rat Egfr/Errp/ERBB1 siRNA oligo Duplex | 24329 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13649 | Pre-made Mouse Egfr/Wa5/wa2 siRNA oligo Duplex | 13649 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613027 | Pre-made Cynomolgus/Rhesus macaque EGFR siRNA oligo Duplex | 613027 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100510799 | Pre-made Cat/Feline EGFR siRNA oligo Duplex | 100510799 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404306 | Pre-made Dog/Canine EGFR siRNA oligo Duplex | 404306 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407217 | Pre-made Bovines/Cattle EGFR siRNA oligo Duplex | 407217 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067755 | Pre-made Equine/Horse EGFR siRNA oligo Duplex | 100067755 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EGFR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|---|---|---|---|---|
| GM-Tg-hg-T59328-Ab | Human | Anti-Human EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T59328-Ab | Rat | Anti-Rat EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T59328-Ab | Mouse | Anti-Mouse EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T59328-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T59328-Ab | Cat/Feline | Anti-Cat/Feline EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T59328-Ab | Dog/Canine | Anti-Dog/Canine EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T59328-Ab | Bovines/Cattle | Anti-Bovines/Cattle EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T59328-Ab | Equine/Horse | Anti-Equine/Horse EGFR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
EGFR VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|---|---|---|---|
| GM-Tg-hg-T59328-Ag | Human | Human EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T59328-Ag | Rat | Rat EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T59328-Ag | Mouse | Mouse EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T59328-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59328-Ag | Cat/Feline | Cat/Feline EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T59328-Ag | Dog/Canine | Dog/Canine EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T59328-Ag | Bovines/Cattle | Bovines/Cattle EGFR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T59328-Ag | Equine/Horse | Equine/Horse EGFR VLP (virus-like particle) | HEK293 | Products Developing |