Explore PKC Zeta/PRKCZ gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Target ID |
GM-T59190
|
Target Name |
PKC Zeta/PRKCZ
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5590
|
Gene ID |
100064240 (Equus caballus), 101087851 (Felis catus), 18762 (Mus musculus), 25522 (Rattus norvegicus) 286877 (Bos taurus), 479577 (Canis lupus familiaris), 5590 (Homo sapiens), 710340 (Macaca mulatta)
|
Target Alternative Names |
PRKCZ,Prkcz,Pkcz,zetaPKC,aPKCzeta,nPKC-zeta,r14-3-3,14-3-3-zetaisoform,PKC2,PKC-ZETA
|
Uniprot Accession |
Q02956,P09217,Q05513
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target
|
Disease |
|
Disease from KEGG |
Rap1 signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Axon guidance, Hippo signaling pathway, Tight junction, Platelet activation, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Human papillomavirus infection, Fluid shear stress and atherosclerosis
|
Gene Ensembl |
ENSECAG00000014312, ENSMUSG00000029053, ENSBTAG00000014119, ENSCAFG00845016558, ENSG00000067606, ENSMMUG00000018911
|
Target Classification |
Kinase
|
Pre-made viral vector of PKC Zeta/PRKCZ cDNA Clones/ORF Plasmid
PKC Zeta/PRKCZ siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo5590 | Pre-made Human PRKCZ/PKC2/PKC-ZETA siRNA oligo Duplex | 5590 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25522 | Pre-made Rat Prkcz/Pkcz/r14-3-3 siRNA oligo Duplex | 25522 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo18762 | Pre-made Mouse Prkcz/Pkcz/zetaPKC siRNA oligo Duplex | 18762 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo710340 | Pre-made Cynomolgus/Rhesus macaque PRKCZ siRNA oligo Duplex | 710340 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101087851 | Pre-made Cat/Feline PRKCZ siRNA oligo Duplex | 101087851 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo479577 | Pre-made Dog/Canine PRKCZ siRNA oligo Duplex | 479577 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo286877 | Pre-made Bovines/Cattle PRKCZ siRNA oligo Duplex | 286877 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100064240 | Pre-made Equine/Horse PRKCZ siRNA oligo Duplex | 100064240 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PKC Zeta/PRKCZ antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T59190-Ab | Human | Anti-Human PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T59190-Ab | Rat | Anti-Rat PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T59190-Ab | Mouse | Anti-Mouse PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T59190-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T59190-Ab | Cat/Feline | Anti-Cat/Feline PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T59190-Ab | Dog/Canine | Anti-Dog/Canine PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T59190-Ab | Bovines/Cattle | Anti-Bovines/Cattle PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T59190-Ab | Equine/Horse | Anti-Equine/Horse PKC Zeta/PRKCZ monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PKC Zeta/PRKCZ VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T59190-Ag | Human | Human PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T59190-Ag | Rat | Rat PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T59190-Ag | Mouse | Mouse PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T59190-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T59190-Ag | Cat/Feline | Cat/Feline PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T59190-Ag | Dog/Canine | Dog/Canine PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T59190-Ag | Bovines/Cattle | Bovines/Cattle PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T59190-Ag | Equine/Horse | Equine/Horse PKC Zeta/PRKCZ VLP (virus-like particle) | HEK293 | Products Developing |