PKC Zeta/PRKCZ Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore PKC Zeta/PRKCZ gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Target ID GM-T59190
Target Name PKC Zeta/PRKCZ
Gene Group ldentifer
(Target Gene ID in Homo species)
5590
Gene ID 100064240 (Equus caballus), 101087851 (Felis catus), 18762 (Mus musculus), 25522 (Rattus norvegicus)
286877 (Bos taurus), 479577 (Canis lupus familiaris), 5590 (Homo sapiens), 710340 (Macaca mulatta)
Target Alternative Names PRKCZ,Prkcz,Pkcz,zetaPKC,aPKCzeta,nPKC-zeta,r14-3-3,14-3-3-zetaisoform,PKC2,PKC-ZETA
Uniprot Accession Q02956,P09217,Q05513
Uniprot Entry Name
Protein Sub-location Transmembrane Protein
Category Therapeutics Target
Disease
Disease from KEGG Rap1 signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Axon guidance, Hippo signaling pathway, Tight junction, Platelet activation, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, AGE-RAGE signaling pathway in diabetic complications, Human papillomavirus infection, Fluid shear stress and atherosclerosis
Gene Ensembl ENSECAG00000014312, ENSMUSG00000029053, ENSBTAG00000014119, ENSCAFG00845016558, ENSG00000067606, ENSMMUG00000018911
Target Classification Kinase


Pre-made viral vector of PKC Zeta/PRKCZ cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP001899Human PRKCZ/PKC-ZETA/PKC2 Lentivirus plasmidNM_002744.5 5590HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMLP005405Human PRKCZ/PKC-ZETA/PKC2 Lentivirus plasmidNM_002744.55590HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP001899Human PRKCZ/PKC-ZETA/PKC2 Lentivirus particleNM_002744.5 5590HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMLP005405Human PRKCZ/PKC-ZETA/PKC2 Lentivirus particleNM_002744.55590HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


PKC Zeta/PRKCZ siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo5590Pre-made Human PRKCZ/PKC2/PKC-ZETA siRNA oligo Duplex5590HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo25522Pre-made Rat Prkcz/Pkcz/r14-3-3 siRNA oligo Duplex25522RatIn-vitro grade; in-vivo gradeDetail
pGMoligo18762Pre-made Mouse Prkcz/Pkcz/zetaPKC siRNA oligo Duplex18762MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo710340Pre-made Cynomolgus/Rhesus macaque PRKCZ siRNA oligo Duplex710340Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101087851Pre-made Cat/Feline PRKCZ siRNA oligo Duplex101087851Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo479577Pre-made Dog/Canine PRKCZ siRNA oligo Duplex479577Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo286877Pre-made Bovines/Cattle PRKCZ siRNA oligo Duplex286877Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100064240Pre-made Equine/Horse PRKCZ siRNA oligo Duplex100064240Equine/HorseIn-vitro grade; in-vivo gradeDetail


PKC Zeta/PRKCZ antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T59190-AbHumanAnti-Human PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-rg-T59190-AbRatAnti-Rat PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-mg-T59190-AbMouseAnti-Mouse PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cynog-T59190-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-felg-T59190-AbCat/FelineAnti-Cat/Feline PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cang-T59190-AbDog/CanineAnti-Dog/Canine PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-bovg-T59190-AbBovines/CattleAnti-Bovines/Cattle PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-equg-T59190-AbEquine/HorseAnti-Equine/Horse PKC Zeta/PRKCZ monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail


PKC Zeta/PRKCZ VLP (virus-like particle)

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T59190-AgHumanHuman PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-rg-T59190-AgRatRat PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-mg-T59190-AgMouseMouse PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-cynog-T59190-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-felg-T59190-AgCat/FelineCat/Feline PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-cang-T59190-AgDog/CanineDog/Canine PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-bovg-T59190-AgBovines/CattleBovines/Cattle PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing
GM-Tg-equg-T59190-AgEquine/HorseEquine/Horse PKC Zeta/PRKCZ VLP (virus-like particle)HEK293Products Developing