Explore CD209 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]
| Target ID |
GM-T59082
|
| Target Name |
CD209
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
30835
|
| Gene ID |
100462978 (Felis catus), 288375 (Rattus norvegicus), 30835 (Homo sapiens)
|
| Target Alternative Names |
C-type lectin domain family 4 member L,CD209,CD209 antigen,CDSIGN,CLEC4L,Cd209a,DC-SIGN,DC-SIGN1,DC-SIGN1),Dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN,hDC-SIGN
|
| Uniprot Accession |
Q9NNX6
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Phagosome, C-type lectin receptor signaling pathway, Tuberculosis, Measles
|
| Gene Ensembl |
ENSG00000090659
|
Pre-made viral vector of CD209 cDNA Clones/ORF Plasmid
CD209 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo30835 | Pre-made Human CD209/CDSIGN/CLEC4L siRNA oligo Duplex | 30835 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo288375 | Pre-made Rat Cd209a siRNA oligo Duplex | 288375 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100462978 | Pre-made Cat/Feline CD209 siRNA oligo Duplex | 100462978 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
CD209 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59082-Ab | Human | Anti-Human CD209 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T59082-Ab | Rat | Anti-Rat CD209 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T59082-Ab | Cat/Feline | Anti-Cat/Feline CD209 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD209 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59082-Ag | Human | Human CD209 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T59082-Ag | Rat | Rat CD209 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59082-Ag | Cat/Feline | Cat/Feline CD209 VLP (virus-like particle) | HEK293 | Products Developing |
