Explore CD16/CD16a/FCGR3A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
| Target ID |
GM-T59001
|
| Target Name |
CD16/CD16a/FCGR3A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2214
|
| Gene ID |
2214 (Homo sapiens), 493677 (Felis catus)
|
| Target Alternative Names |
CD16,CD16-II,CD16A,CD16a,CD16a antigen,FCG3,FCGR3,FCGR3A,FCGRIII,FCR-10,FCRIII,FCRIIIA,Fc-gamma RIII-alpha (Fc-gamma RIII,Fc-gamma RIIIa,FcGRIIIA,FcR-10,FcRIII,FcRIIIa,FcgammaRIIIA),IGFR3,IMD20,IgG Fc receptor III-2,IgG Fc receptor III-A,Low affinity immunoglobulin gamma Fc region receptor III-A
|
| Uniprot Accession |
P08637,Q9N2I5
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, Leishmaniasis, Staphylococcus aureus infection, Tuberculosis
|
| Gene Ensembl |
ENSG00000203747
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD16/CD16a/FCGR3A cDNA Clones/ORF Plasmid
CD16/CD16a/FCGR3A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2214 | Pre-made Human FCGR3A/CD16/FCG3 siRNA oligo Duplex | 2214 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493677 | Pre-made Cat/Feline FCGR3A/CD16/FCGR3 siRNA oligo Duplex | 493677 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
CD16/CD16a/FCGR3A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59001-Ab | Human | Anti-Human CD16/CD16a/FCGR3A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T59001-Ab | Cat/Feline | Anti-Cat/Feline CD16/CD16a/FCGR3A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD16/CD16a/FCGR3A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59001-Ag | Human | Human CD16/CD16a/FCGR3A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59001-Ag | Cat/Feline | Cat/Feline CD16/CD16a/FCGR3A VLP (virus-like particle) | HEK293 | Products Developing |
