Explore SCN8A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
| Target ID |
GM-T58741
|
| Target Name |
SCN8A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6334
|
| Gene ID |
100052777 (Equus caballus), 101096578 (Felis catus), 20273 (Mus musculus), 29710 (Rattus norvegicus)
477604 (Canis lupus familiaris), 537277 (Bos taurus), 6334 (Homo sapiens), 695972 (Macaca mulatta)
|
| Target Alternative Names |
BFIS5,C630029C19Rik,CERIII,CIAT,DEE13,EIEE13,MED,MYOCL2,NaCh6,Nav1.6,PN4,SCN8A,Scn8a,Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6,dmu,med,mnd-2,mnd2,nmf2,nmf335,nmf58,nur14,seal
|
| Uniprot Accession |
Q9WTU3,O88420,Q9UQD0
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000010751, ENSMUSG00000023033, ENSCAFG00845027770, ENSBTAG00000021339, ENSG00000196876, ENSMMUG00000000415
|
| Target Classification |
Ion Channel
|
SCN8A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6334 | Pre-made Human SCN8A/MED/PN4 siRNA oligo Duplex | 6334 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29710 | Pre-made Rat Scn8a siRNA oligo Duplex | 29710 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20273 | Pre-made Mouse Scn8a/dmu/med siRNA oligo Duplex | 20273 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695972 | Pre-made Cynomolgus/Rhesus macaque SCN8A siRNA oligo Duplex | 695972 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096578 | Pre-made Cat/Feline SCN8A siRNA oligo Duplex | 101096578 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477604 | Pre-made Dog/Canine SCN8A siRNA oligo Duplex | 477604 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo537277 | Pre-made Bovines/Cattle SCN8A siRNA oligo Duplex | 537277 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052777 | Pre-made Equine/Horse SCN8A siRNA oligo Duplex | 100052777 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SCN8A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T58741-Ab | Human | Anti-Human SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T58741-Ab | Rat | Anti-Rat SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T58741-Ab | Mouse | Anti-Mouse SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T58741-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T58741-Ab | Cat/Feline | Anti-Cat/Feline SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T58741-Ab | Dog/Canine | Anti-Dog/Canine SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T58741-Ab | Bovines/Cattle | Anti-Bovines/Cattle SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T58741-Ab | Equine/Horse | Anti-Equine/Horse SCN8A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SCN8A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T58741-Ag | Human | Human SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T58741-Ag | Rat | Rat SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T58741-Ag | Mouse | Mouse SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T58741-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T58741-Ag | Cat/Feline | Cat/Feline SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T58741-Ag | Dog/Canine | Dog/Canine SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T58741-Ag | Bovines/Cattle | Bovines/Cattle SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T58741-Ag | Equine/Horse | Equine/Horse SCN8A VLP (virus-like particle) | HEK293 | Products Developing |
