Explore FGFR2/CD332 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Target ID |
GM-T58454
|
Target Name |
FGFR2/CD332
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2263
|
Gene ID |
100033956 (Equus caballus), 101095198 (Felis catus), 14183 (Mus musculus), 2263 (Homo sapiens) 25022 (Rattus norvegicus), 404193 (Bos taurus), 415125 (Canis lupus familiaris), 715949 (Macaca mulatta)
|
Target Alternative Names |
BBDS,BEK,BFR-1,Bek,CD332,CEK3,CFD1,ECT1,FGFR,FGFR-2,FGFR2,FGFR2IIIC,Fgfr-2,Fgfr-7,Fgfr2,Fgfr2b,Fgfr7,Fibroblast growth factor receptor 2,JWS,K-SAM,K-sam (KGFR),KGFR,KGFRTr,Keratinocyte growth factor receptor,TK14,TK25,fgfr2IIIb,fgfr2IIIc,svs
|
Uniprot Accession |
P21803,P21802
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target, INN Index, Cytokine Target
|
Disease |
cancer, Non-Small Cell Lung Cancer
|
Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer, Gastric cancer, Central carbon metabolism in cancer
|
Gene Ensembl |
ENSECAG00000013960, ENSMUSG00000030849, ENSG00000066468, ENSBTAG00000014064, ENSCAFG00845019372, ENSMMUG00000009594
|
Target Classification |
Kinase
|
Pre-made viral vector of FGFR2/CD332 cDNA Clones/ORF Plasmid
FGFR2/CD332 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo2263 | Pre-made Human FGFR2/BEK/JWS siRNA oligo Duplex | 2263 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25022 | Pre-made Rat Fgfr2/KGFR siRNA oligo Duplex | 25022 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo14183 | Pre-made Mouse Fgfr2/Bek/svs siRNA oligo Duplex | 14183 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo715949 | Pre-made Cynomolgus/Rhesus macaque FGFR2 siRNA oligo Duplex | 715949 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101095198 | Pre-made Cat/Feline FGFR2 siRNA oligo Duplex | 101095198 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo415125 | Pre-made Dog/Canine FGFR2/FGFR2IIIC siRNA oligo Duplex | 415125 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo404193 | Pre-made Bovines/Cattle FGFR2/FGFR siRNA oligo Duplex | 404193 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033956 | Pre-made Equine/Horse FGFR2/fgfr2IIIb/fgfr2IIIc siRNA oligo Duplex | 100033956 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FGFR2/CD332 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T58454-Ab | Human | Anti-Human FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T58454-Ab | Rat | Anti-Rat FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T58454-Ab | Mouse | Anti-Mouse FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T58454-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T58454-Ab | Cat/Feline | Anti-Cat/Feline FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T58454-Ab | Dog/Canine | Anti-Dog/Canine FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T58454-Ab | Bovines/Cattle | Anti-Bovines/Cattle FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T58454-Ab | Equine/Horse | Anti-Equine/Horse FGFR2/CD332 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
FGFR2/CD332 VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T58454-Ag | Human | Human FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T58454-Ag | Rat | Rat FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T58454-Ag | Mouse | Mouse FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T58454-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T58454-Ag | Cat/Feline | Cat/Feline FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T58454-Ag | Dog/Canine | Dog/Canine FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T58454-Ag | Bovines/Cattle | Bovines/Cattle FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T58454-Ag | Equine/Horse | Equine/Horse FGFR2/CD332 VLP (virus-like particle) | HEK293 | Products Developing |