Explore EPHA2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
| Target ID |
GM-T57278
|
| Target Name |
EPHA2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1969
|
| Gene ID |
100053644 (Equus caballus), 101085481 (Felis catus), 13836 (Mus musculus), 1969 (Homo sapiens)
366492 (Rattus norvegicus), 487421 (Canis lupus familiaris), 512798 (Bos taurus), 692343 (Macaca mulatta)
|
| Target Alternative Names |
ARCC2,CTPA,CTPP1,CTRCT6,ECK,EPHA2,Eck,Epha2,Ephrin type-A receptor 2,Epithelial cell kinase,Myk2,Sek-2,Sek2,Tyrosine-protein kinase receptor ECK
|
| Uniprot Accession |
Q03145,P29317
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Axon guidance
|
| Gene Ensembl |
ENSECAG00000007650, ENSMUSG00000006445, ENSG00000142627, ENSCAFG00845004794, ENSBTAG00000000815, ENSMMUG00000018245
|
| Target Classification |
Kinase, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of EPHA2 cDNA Clones/ORF Plasmid
EPHA2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1969 | Pre-made Human EPHA2/ECK/CTPA siRNA oligo Duplex | 1969 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo366492 | Pre-made Rat Epha2 siRNA oligo Duplex | 366492 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13836 | Pre-made Mouse Epha2/Eck/Myk2 siRNA oligo Duplex | 13836 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692343 | Pre-made Cynomolgus/Rhesus macaque EPHA2 siRNA oligo Duplex | 692343 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085481 | Pre-made Cat/Feline EPHA2 siRNA oligo Duplex | 101085481 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487421 | Pre-made Dog/Canine EPHA2 siRNA oligo Duplex | 487421 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512798 | Pre-made Bovines/Cattle EPHA2 siRNA oligo Duplex | 512798 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053644 | Pre-made Equine/Horse EPHA2 siRNA oligo Duplex | 100053644 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EPHA2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T57278-Ab | Human | Anti-Human EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T57278-Ab | Rat | Anti-Rat EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T57278-Ab | Mouse | Anti-Mouse EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T57278-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T57278-Ab | Cat/Feline | Anti-Cat/Feline EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T57278-Ab | Dog/Canine | Anti-Dog/Canine EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T57278-Ab | Bovines/Cattle | Anti-Bovines/Cattle EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T57278-Ab | Equine/Horse | Anti-Equine/Horse EPHA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
EPHA2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T57278-Ag | Human | Human EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T57278-Ag | Rat | Rat EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T57278-Ag | Mouse | Mouse EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T57278-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T57278-Ag | Cat/Feline | Cat/Feline EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T57278-Ag | Dog/Canine | Dog/Canine EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T57278-Ag | Bovines/Cattle | Bovines/Cattle EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T57278-Ag | Equine/Horse | Equine/Horse EPHA2 VLP (virus-like particle) | HEK293 | Products Developing |
