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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
| Target ID |
GM-T56121
|
| Target Name |
EPHB3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2049
|
| Gene ID |
100067381 (Equus caballus), 101094200 (Felis catus), 13845 (Mus musculus), 2049 (Homo sapiens)
287989 (Rattus norvegicus), 488108 (Canis lupus familiaris), 540907 (Bos taurus), 701811 (Macaca mulatta)
|
| Target Alternative Names |
Cek10,EK2,EPH-like tyrosine kinase 2 (EPH-like kinase 2),EPHB3,ETK2,Embryonic kinase 2 (EK2,Ephb3,Ephrin type-B receptor 3,Etk2,HEK2,MDK5,Sek4,TYRO6,Tyro6,Tyrosine-protein kinase TYRO6,hEK2),mDK-5
|
| Uniprot Accession |
P54754,P54753
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Axon guidance
|
| Gene Ensembl |
ENSECAG00000009755, ENSMUSG00000005958, ENSG00000182580, ENSCAFG00845028919, ENSBTAG00000005313, ENSMMUG00000003304
|
| Target Classification |
Kinase
|
Pre-made viral vector of EPHB3 cDNA Clones/ORF Plasmid
EPHB3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2049 | Pre-made Human EPHB3/EK2/ETK2 siRNA oligo Duplex | 2049 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287989 | Pre-made Rat Ephb3 siRNA oligo Duplex | 287989 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13845 | Pre-made Mouse Ephb3/Etk2/HEK2 siRNA oligo Duplex | 13845 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701811 | Pre-made Cynomolgus/Rhesus macaque EPHB3 siRNA oligo Duplex | 701811 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094200 | Pre-made Cat/Feline EPHB3 siRNA oligo Duplex | 101094200 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488108 | Pre-made Dog/Canine EPHB3 siRNA oligo Duplex | 488108 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540907 | Pre-made Bovines/Cattle EPHB3 siRNA oligo Duplex | 540907 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067381 | Pre-made Equine/Horse EPHB3 siRNA oligo Duplex | 100067381 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
EPHB3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T56121-Ab | Human | Anti-Human EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T56121-Ab | Rat | Anti-Rat EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T56121-Ab | Mouse | Anti-Mouse EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T56121-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T56121-Ab | Cat/Feline | Anti-Cat/Feline EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T56121-Ab | Dog/Canine | Anti-Dog/Canine EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T56121-Ab | Bovines/Cattle | Anti-Bovines/Cattle EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T56121-Ab | Equine/Horse | Anti-Equine/Horse EPHB3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
EPHB3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T56121-Ag | Human | Human EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T56121-Ag | Rat | Rat EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T56121-Ag | Mouse | Mouse EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T56121-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T56121-Ag | Cat/Feline | Cat/Feline EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T56121-Ag | Dog/Canine | Dog/Canine EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T56121-Ag | Bovines/Cattle | Bovines/Cattle EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T56121-Ag | Equine/Horse | Equine/Horse EPHB3 VLP (virus-like particle) | HEK293 | Products Developing |
