Explore KCNQ4 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T55916
|
| Target Name |
KCNQ4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9132
|
| Gene ID |
100067963 (Equus caballus), 100426025 (Macaca mulatta), 101091641 (Felis catus), 298496 (Rattus norvegicus)
482451 (Canis lupus familiaris), 528741 (Bos taurus), 60613 (Mus musculus), 9132 (Homo sapiens)
|
| Target Alternative Names |
DFNA2,DFNA2A,KCNQ4,KQT-like 4,KV7.4,Kcnq4,Potassium channel subunit alpha KvLQT4,Potassium voltage-gated channel subfamily KQT member 4,Voltage-gated potassium channel subunit Kv7.4
|
| Uniprot Accession |
Q9JK96,Q9JK97,P56696
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Cholinergic synapse
|
| Gene Ensembl |
ENSECAG00000021257, ENSMMUG00000019536, ENSCAFG00845009123, ENSBTAG00000002644, ENSMUSG00000028631, ENSG00000117013
|
| Target Classification |
Ion Channel
|
KCNQ4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9132 | Pre-made Human KCNQ4/DFNA2/KV7.4 siRNA oligo Duplex | 9132 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo298496 | Pre-made Rat Kcnq4 siRNA oligo Duplex | 298496 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo60613 | Pre-made Mouse Kcnq4 siRNA oligo Duplex | 60613 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100426025 | Pre-made Cynomolgus/Rhesus macaque KCNQ4 siRNA oligo Duplex | 100426025 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101091641 | Pre-made Cat/Feline KCNQ4 siRNA oligo Duplex | 101091641 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482451 | Pre-made Dog/Canine KCNQ4 siRNA oligo Duplex | 482451 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo528741 | Pre-made Bovines/Cattle KCNQ4 siRNA oligo Duplex | 528741 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067963 | Pre-made Equine/Horse KCNQ4 siRNA oligo Duplex | 100067963 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNQ4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T55916-Ab | Human | Anti-Human KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T55916-Ab | Rat | Anti-Rat KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T55916-Ab | Mouse | Anti-Mouse KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T55916-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T55916-Ab | Cat/Feline | Anti-Cat/Feline KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T55916-Ab | Dog/Canine | Anti-Dog/Canine KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T55916-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T55916-Ab | Equine/Horse | Anti-Equine/Horse KCNQ4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNQ4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T55916-Ag | Human | Human KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T55916-Ag | Rat | Rat KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T55916-Ag | Mouse | Mouse KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T55916-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T55916-Ag | Cat/Feline | Cat/Feline KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T55916-Ag | Dog/Canine | Dog/Canine KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T55916-Ag | Bovines/Cattle | Bovines/Cattle KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T55916-Ag | Equine/Horse | Equine/Horse KCNQ4 VLP (virus-like particle) | HEK293 | Products Developing |
