Explore CD49b/Integrin alpha 2/ITGA2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
| Target ID |
GM-T55293
|
| Target Name |
CD49b/Integrin alpha 2/ITGA2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3673
|
| Gene ID |
100063367 (Equus caballus), 101090237 (Felis catus), 16398 (Mus musculus), 170921 (Rattus norvegicus)
281872 (Bos taurus), 3673 (Homo sapiens), 489208 (Canis lupus familiaris), 703572 (Macaca mulatta)
|
| Target Alternative Names |
BR,CD49 antigen-like family member B,CD49B,CD49b,Collagen receptor,DX5,GPIa,HPA-5,ITGA2,Integrin alpha 2,Integrin alpha-2,Itga2,Platelet membrane glycoprotein Ia (GPIa),VLA-2,VLA-2 subunit alpha,VLAA2
|
| Uniprot Accession |
Q62469,P53710,P17301
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
Phagosome, PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, Regulation of actin cytoskeleton, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Small cell lung cancer, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000010739, ENSMUSG00000015533, ENSBTAG00000019289, ENSG00000164171, ENSCAFG00845000432, ENSMMUG00000020448
|
CD49b/Integrin alpha 2/ITGA2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3673 | Pre-made Human ITGA2/BR/GPIa siRNA oligo Duplex | 3673 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170921 | Pre-made Rat Itga2/GPIa/CD49B siRNA oligo Duplex | 170921 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16398 | Pre-made Mouse Itga2/DX5/GPIa siRNA oligo Duplex | 16398 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703572 | Pre-made Cynomolgus/Rhesus macaque ITGA2 siRNA oligo Duplex | 703572 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090237 | Pre-made Cat/Feline ITGA2 siRNA oligo Duplex | 101090237 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489208 | Pre-made Dog/Canine ITGA2 siRNA oligo Duplex | 489208 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281872 | Pre-made Bovines/Cattle ITGA2 siRNA oligo Duplex | 281872 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063367 | Pre-made Equine/Horse ITGA2 siRNA oligo Duplex | 100063367 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD49b/Integrin alpha 2/ITGA2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T55293-Ab | Human | Anti-Human CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T55293-Ab | Rat | Anti-Rat CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T55293-Ab | Mouse | Anti-Mouse CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T55293-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T55293-Ab | Cat/Feline | Anti-Cat/Feline CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T55293-Ab | Dog/Canine | Anti-Dog/Canine CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T55293-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T55293-Ab | Equine/Horse | Anti-Equine/Horse CD49b/Integrin alpha 2/ITGA2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T55293-Ag | Human | Human CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T55293-Ag | Rat | Rat CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T55293-Ag | Mouse | Mouse CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T55293-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T55293-Ag | Cat/Feline | Cat/Feline CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T55293-Ag | Dog/Canine | Dog/Canine CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T55293-Ag | Bovines/Cattle | Bovines/Cattle CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T55293-Ag | Equine/Horse | Equine/Horse CD49b/Integrin alpha 2/ITGA2 VLP (virus-like particle) | HEK293 | Products Developing |
