Explore KCNQ3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
| Target ID |
GM-T54132
|
| Target Name |
KCNQ3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3786
|
| Gene ID |
100057886 (Equus caballus), 101093496 (Felis catus), 110862 (Mus musculus), 281884 (Bos taurus)
29682 (Rattus norvegicus), 3786 (Homo sapiens), 475103 (Canis lupus familiaris), 700785 (Macaca mulatta)
|
| Target Alternative Names |
BFNC2,EBN2,KCNQ3,KQT-like 3,KV7.3,Kcnq3,Potassium channel subunit alpha KvLQT3,Potassium voltage-gated channel subfamily KQT member 3,Voltage-gated potassium channel subunit Kv7.3
|
| Uniprot Accession |
Q8K3F6,P58126,O88944,O43525
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Cholinergic synapse
|
| Gene Ensembl |
ENSECAG00000017467, ENSMUSG00000056258, ENSBTAG00000020667, ENSG00000184156, ENSCAFG00845007700, ENSMMUG00000000892
|
| Target Classification |
Ion Channel
|
KCNQ3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3786 | Pre-made Human KCNQ3/EBN2/BFNC2 siRNA oligo Duplex | 3786 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29682 | Pre-made Rat Kcnq3 siRNA oligo Duplex | 29682 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo110862 | Pre-made Mouse Kcnq3 siRNA oligo Duplex | 110862 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700785 | Pre-made Cynomolgus/Rhesus macaque KCNQ3 siRNA oligo Duplex | 700785 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093496 | Pre-made Cat/Feline KCNQ3 siRNA oligo Duplex | 101093496 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475103 | Pre-made Dog/Canine KCNQ3 siRNA oligo Duplex | 475103 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281884 | Pre-made Bovines/Cattle KCNQ3 siRNA oligo Duplex | 281884 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057886 | Pre-made Equine/Horse KCNQ3 siRNA oligo Duplex | 100057886 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNQ3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T54132-Ab | Human | Anti-Human KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T54132-Ab | Rat | Anti-Rat KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T54132-Ab | Mouse | Anti-Mouse KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T54132-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T54132-Ab | Cat/Feline | Anti-Cat/Feline KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T54132-Ab | Dog/Canine | Anti-Dog/Canine KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T54132-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T54132-Ab | Equine/Horse | Anti-Equine/Horse KCNQ3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNQ3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T54132-Ag | Human | Human KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T54132-Ag | Rat | Rat KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T54132-Ag | Mouse | Mouse KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T54132-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T54132-Ag | Cat/Feline | Cat/Feline KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T54132-Ag | Dog/Canine | Dog/Canine KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T54132-Ag | Bovines/Cattle | Bovines/Cattle KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T54132-Ag | Equine/Horse | Equine/Horse KCNQ3 VLP (virus-like particle) | HEK293 | Products Developing |
