Explore CRLF2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
| Target ID |
GM-T53669
|
| Target Name |
CRLF2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
64109
|
| Gene ID |
101100367 (Felis catus), 102150794 (Equus caballus), 106995742 (Macaca mulatta), 132342113 (Bos taurus)
171499 (Rattus norvegicus), 491709 (Canis lupus familiaris), 57914 (Mus musculus), 64109 (Homo sapiens)
|
| Target Alternative Names |
CRL2,CRLF2,CRLF2Y,CRLM2,Crl2,Crlf2,Cytokine receptor-like 2,Cytokine receptor-like factor 2,IL-XR,Ly114,TSLPR,Thymic stromal lymphopoietin protein receptor (TSLP receptor),Tpte2,Tslpr
|
| Uniprot Accession |
Q8R4S8,Q8CII9,Q9HC73
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSMMUG00000051095, ENSCAFG00845020961, ENSMUSG00000033467, ENSG00000205755,ENSG00000292363
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CRLF2 cDNA Clones/ORF Plasmid
CRLF2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo64109 | Pre-made Human CRLF2/CRL2/TSLPR siRNA oligo Duplex | 64109 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171499 | Pre-made Rat Crlf2/Crl2/Tpte2 siRNA oligo Duplex | 171499 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo57914 | Pre-made Mouse Crlf2/CRLM2/Ly114 siRNA oligo Duplex | 57914 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo106995742 | Pre-made Cynomolgus/Rhesus macaque CRLF2 siRNA oligo Duplex | 106995742 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100367 | Pre-made Cat/Feline CRLF2 siRNA oligo Duplex | 101100367 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491709 | Pre-made Dog/Canine CRLF2 siRNA oligo Duplex | 491709 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo132342113 | Pre-made Bovines/Cattle CRLF2 siRNA oligo Duplex | 132342113 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102150794 | Pre-made Equine/Horse CRLF2 siRNA oligo Duplex | 102150794 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CRLF2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53669-Ab | Human | Anti-Human CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T53669-Ab | Rat | Anti-Rat CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T53669-Ab | Mouse | Anti-Mouse CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T53669-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T53669-Ab | Cat/Feline | Anti-Cat/Feline CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T53669-Ab | Dog/Canine | Anti-Dog/Canine CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T53669-Ab | Bovines/Cattle | Anti-Bovines/Cattle CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T53669-Ab | Equine/Horse | Anti-Equine/Horse CRLF2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CRLF2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53669-Ag | Human | Human CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T53669-Ag | Rat | Rat CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T53669-Ag | Mouse | Mouse CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T53669-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T53669-Ag | Cat/Feline | Cat/Feline CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T53669-Ag | Dog/Canine | Dog/Canine CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T53669-Ag | Bovines/Cattle | Bovines/Cattle CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T53669-Ag | Equine/Horse | Equine/Horse CRLF2 VLP (virus-like particle) | HEK293 | Products Developing |
