Explore Caspase 4/p20/p10/CASP4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T53469
|
| Target Name |
Caspase 4/p20/p10/CASP4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
837
|
| Gene ID |
704864 (Macaca mulatta), 837 (Homo sapiens)
|
| Target Alternative Names |
CASP4,TX,Mih1,ICH-2,Mih1/TX,ICEREL-II,ICE(rel)II
|
| Uniprot Accession |
P49662
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
NOD-like receptor signaling pathway, Pathogenic Escherichia coli infection
|
| Gene Ensembl |
ENSMMUG00000009850, ENSG00000196954
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Caspase 4/p20/p10/CASP4 cDNA Clones/ORF Plasmid
Caspase 4/p20/p10/CASP4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo837 | Pre-made Human CASP4/TX/Mih1 siRNA oligo Duplex | 837 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704864 | Pre-made Cynomolgus/Rhesus macaque CASP4 siRNA oligo Duplex | 704864 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
Caspase 4/p20/p10/CASP4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53469-Ab | Human | Anti-Human Caspase 4/p20/p10/CASP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T53469-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Caspase 4/p20/p10/CASP4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Caspase 4/p20/p10/CASP4 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53469-Ag | Human | Human Caspase 4/p20/p10/CASP4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T53469-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Caspase 4/p20/p10/CASP4 VLP (virus-like particle) | HEK293 | Products Developing |
