Explore TNFR2/TNFRSF1B/CD120b/TNF-R2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T53033
|
| Target Name |
TNFR2/TNFRSF1B/CD120b/TNF-R2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7133
|
| Gene ID |
100055840 (Equus caballus), 101080392 (Felis catus), 156767 (Rattus norvegicus), 21938 (Mus musculus)
338033 (Bos taurus), 487437 (Canis lupus familiaris), 7133 (Homo sapiens), 715454 (Macaca mulatta)
|
| Target Alternative Names |
CD120b,TBPII,TNF-R-II,TNF-R2,TNF-R75,TNF-RII/TNFRSF1B,TNF-alphaR2,TNFBR,TNFR-II),TNFR1B,TNFR2,TNFR80,TNFRII,TNFRSF1B,TNFalpha-R2,Tnfr-1,Tnfr2,Tnfrsf1b,Tumor necrosis factor receptor 2 (TNF-R2),Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor receptor type II (TNF-RII,p75,p75TNFR,p80 TNF-alpha receptor
|
| Uniprot Accession |
Q80WY6,P25119,P20333
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease |
cancer, Ovary Cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Adipocytokine signaling pathway
|
| Gene Ensembl |
ENSECAG00000012481, ENSMUSG00000028599, ENSBTAG00000024928, ENSCAFG00845001488, ENSG00000028137, ENSMMUG00000021447
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
Pre-made viral vector of TNFR2/TNFRSF1B/CD120b/TNF-R2 cDNA Clones/ORF Plasmid
TNFR2/TNFRSF1B/CD120b/TNF-R2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7133 | Pre-made Human TNFRSF1B/p75/TBPII siRNA oligo Duplex | 7133 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo156767 | Pre-made Rat Tnfrsf1b/Tnfr2 siRNA oligo Duplex | 156767 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21938 | Pre-made Mouse Tnfrsf1b/p75/TNFBR siRNA oligo Duplex | 21938 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715454 | Pre-made Cynomolgus/Rhesus macaque TNFRSF1B siRNA oligo Duplex | 715454 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080392 | Pre-made Cat/Feline TNFRSF1B siRNA oligo Duplex | 101080392 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487437 | Pre-made Dog/Canine TNFRSF1B siRNA oligo Duplex | 487437 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo338033 | Pre-made Bovines/Cattle TNFRSF1B/TNF-RII/TNFRSF1B siRNA oligo Duplex | 338033 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055840 | Pre-made Equine/Horse TNFRSF1B siRNA oligo Duplex | 100055840 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TNFR2/TNFRSF1B/CD120b/TNF-R2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53033-Ab | Human | Anti-Human TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T53033-Ab | Rat | Anti-Rat TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T53033-Ab | Mouse | Anti-Mouse TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T53033-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T53033-Ab | Cat/Feline | Anti-Cat/Feline TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T53033-Ab | Dog/Canine | Anti-Dog/Canine TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T53033-Ab | Bovines/Cattle | Anti-Bovines/Cattle TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T53033-Ab | Equine/Horse | Anti-Equine/Horse TNFR2/TNFRSF1B/CD120b/TNF-R2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53033-Ag | Human | Human TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T53033-Ag | Rat | Rat TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T53033-Ag | Mouse | Mouse TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T53033-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T53033-Ag | Cat/Feline | Cat/Feline TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T53033-Ag | Dog/Canine | Dog/Canine TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T53033-Ag | Bovines/Cattle | Bovines/Cattle TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T53033-Ag | Equine/Horse | Equine/Horse TNFR2/TNFRSF1B/CD120b/TNF-R2 VLP (virus-like particle) | HEK293 | Products Developing |
