Explore MMP1/MMP-1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Target ID |
GM-T52450
|
Target Name |
MMP1/MMP-1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4312
|
Gene ID |
100033896 (Equus caballus), 281308 (Bos taurus), 4312 (Homo sapiens), 489428 (Canis lupus familiaris) 703653 (Macaca mulatta)
|
Target Alternative Names |
MMP1,MMP-1,CLG,CLGN
|
Uniprot Accession |
Q9XSZ5,P28053,P03956
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target
|
Disease |
cancer, Breast Cancer, Intrahepatic bile duct carcinoma
|
Disease from KEGG |
PPAR signaling pathway, IL-17 signaling pathway, Relaxin signaling pathway, Pathways in cancer, Bladder cancer, Rheumatoid arthritis, Lipid and atherosclerosis
|
Gene Ensembl |
ENSECAG00000046821, ENSBTAG00000015818, ENSG00000196611, ENSCAFG00845000871, ENSMMUG00000002037
|
Target Classification |
|
Pre-made viral vector of MMP1/MMP-1 cDNA Clones/ORF Plasmid
MMP1/MMP-1 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo4312 | Pre-made Human MMP1/CLG/CLGN siRNA oligo Duplex | 4312 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo703653 | Pre-made Cynomolgus/Rhesus macaque MMP1 siRNA oligo Duplex | 703653 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo489428 | Pre-made Dog/Canine MMP1 siRNA oligo Duplex | 489428 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo281308 | Pre-made Bovines/Cattle MMP1/MMP-1 siRNA oligo Duplex | 281308 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033896 | Pre-made Equine/Horse MMP1/MMP-1 siRNA oligo Duplex | 100033896 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MMP1/MMP-1 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T52450-Ab | Human | Anti-Human MMP1/MMP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T52450-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MMP1/MMP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T52450-Ab | Dog/Canine | Anti-Dog/Canine MMP1/MMP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T52450-Ab | Bovines/Cattle | Anti-Bovines/Cattle MMP1/MMP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T52450-Ab | Equine/Horse | Anti-Equine/Horse MMP1/MMP-1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MMP1/MMP-1 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T52450-Ag | Human | Human MMP1/MMP-1 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T52450-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MMP1/MMP-1 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T52450-Ag | Dog/Canine | Dog/Canine MMP1/MMP-1 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T52450-Ag | Bovines/Cattle | Bovines/Cattle MMP1/MMP-1 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T52450-Ag | Equine/Horse | Equine/Horse MMP1/MMP-1 recombinant protein | Mammalian cell | Detail |