Explore ACLY gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
| Target ID |
GM-T52189
|
| Target Name |
ACLY
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
47
|
| Gene ID |
100053195 (Equus caballus), 100422779 (Felis catus), 104112 (Mus musculus), 24159 (Rattus norvegicus)
47 (Homo sapiens), 511135 (Bos taurus), 607852 (Canis lupus familiaris), 708501 (Macaca mulatta)
|
| Target Alternative Names |
A730098H14Rik,ACL,ACLY,ATP-citrate (pro-S-)-lyase (ACL),ATP-citrate synthase,ATPCL,Acly,CLATP,Citrate cleavage enzyme,Clatp
|
| Uniprot Accession |
Q91V92,P16638,P53396,Q32PF2
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000009702, ENSMUSG00000020917, ENSG00000131473, ENSBTAG00000016740, ENSCAFG00845011071, ENSMMUG00000018931
|
| Target Classification |
|
Pre-made viral vector of ACLY cDNA Clones/ORF Plasmid
ACLY siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo47 | Pre-made Human ACLY/ACL/ATPCL siRNA oligo Duplex | 47 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24159 | Pre-made Rat Acly/ACL/Clatp siRNA oligo Duplex | 24159 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo104112 | Pre-made Mouse Acly/A730098H14Rik siRNA oligo Duplex | 104112 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708501 | Pre-made Cynomolgus/Rhesus macaque ACLY siRNA oligo Duplex | 708501 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100422779 | Pre-made Cat/Feline ACLY/ACL siRNA oligo Duplex | 100422779 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo607852 | Pre-made Dog/Canine ACLY siRNA oligo Duplex | 607852 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511135 | Pre-made Bovines/Cattle ACLY siRNA oligo Duplex | 511135 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053195 | Pre-made Equine/Horse ACLY siRNA oligo Duplex | 100053195 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ACLY antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T52189-Ab | Human | Anti-Human ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T52189-Ab | Rat | Anti-Rat ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T52189-Ab | Mouse | Anti-Mouse ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T52189-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T52189-Ab | Cat/Feline | Anti-Cat/Feline ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T52189-Ab | Dog/Canine | Anti-Dog/Canine ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T52189-Ab | Bovines/Cattle | Anti-Bovines/Cattle ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T52189-Ab | Equine/Horse | Anti-Equine/Horse ACLY monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ACLY VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T52189-Ag | Human | Human ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T52189-Ag | Rat | Rat ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T52189-Ag | Mouse | Mouse ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T52189-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T52189-Ag | Cat/Feline | Cat/Feline ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T52189-Ag | Dog/Canine | Dog/Canine ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T52189-Ag | Bovines/Cattle | Bovines/Cattle ACLY VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T52189-Ag | Equine/Horse | Equine/Horse ACLY VLP (virus-like particle) | HEK293 | Products Developing |
